Regulator of G-Protein Signalling 19 (RGS19) (pSer24) antibody

Details for Product No. ABIN389781
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Antigen
Synonyms RGS19, GAIP, RGSGAIP, 2610042F04Rik, AI324841, AW547781, Camki, Gaip
Epitope
pSer24
(20), (18), (13), (13), (7), (6), (6), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(103), (63), (61), (24), (24), (24)
Host
Rabbit
(99), (2), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (5), (5), (5), (5), (5), (5), (5), (5), (3), (3), (3)
Application
Dot Blot (DB)
(50), (41), (25), (18), (17), (8), (1), (1)
Pubmed 8 references available
Quantity 400 µL
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Catalog No. ABIN389781
291.50 $
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Immunogen This RGS19 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S24 of human RGS19.
Clone RB11890
Isotype Ig
Specificity This Phospho-RGS19-S24 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 9~39 amino acids surrounding S24 of human RGS19. Patent pending.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RGS19
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.
Synonyms: Regulator of G-protein signaling 19, RGS19, G-alpha interacting protein, GAIP protein, GS19, GAIP, GNAI3IP
Molecular Weight 24636 DA
Gene ID 10287
UniProt P49795
Research Area Cell Signaling, Cell Structure, Autophagy, Phospho-specific antibodies
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Regulator of G-Protein Signalling 19 (RGS19) (pSer24) antibody Dot blot analysis of Phospho-RGS19-S24 Antibody (ABIN389781) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL.
Background publications De Vries, Elenko, Hubler et al.: "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 26, pp. 15203-8, 1997 (PubMed).

de Alba, De Vries, Farquhar et al.: "Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling." in: Journal of molecular biology, Vol. 291, Issue 4, pp. 927-39, 1999 (PubMed).

Ogier-Denis, Pattingre, El Benna et al.: "Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39090-5, 2001 (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, 2004 (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." in: Cell, Vol. 120, Issue 2, pp. 159-62, 2005 (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, 2005 (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, 2005 (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." in: Developmental cell, Vol. 8, Issue 6, pp. 799-801, 2005 (PubMed).

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