RGS19 antibody (N-Term)

Catalog No. ABIN6243052

Cited in 2+ publications. The Rabbit Polyclonal anti-RGS19 antibody (Clone RB7576) (ABIN6243052) specifically detects RGS19 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for RGS19 antibody (N-Term) (ABIN6243052)

Target: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS19 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7576

Product Details anti-RGS19 Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RGS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-term of human RGS19.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RGS19 antibody (ABIN6243052)

Li, Wang, Chen, Lu, Wang, Duan, Tian, Wang, You, Zou, Cheng, Zhu, Wan, Xi, Jiang, Han, Cao, Birnbaumer, Chu, Yang: "Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 15, pp. 4731-6, (2015) (PubMed).

Sanchez, Penfornis, Oskowitz, Boonjindasup, Cai, Dhule, Rowan, Kelekar, Krause, Pochampally: "Activation of autophagy in mesenchymal stem cells provides tumor stromal support." in: Carcinogenesis, Vol. 32, Issue 7, pp. 964-72, (2011) (PubMed).

Target Details for RGS19

Target: RGS19 (Regulator of G-Protein Signalling 19 (RGS19))

Alternative Name: RGS19

Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). RGS19 enhances the intrinsic GTPase-activating protein activity of the Galphai3 protein, which stimulates autophagy by favoring the GDP-bound form of Galphai3.

Molecular Weight: 24636

NCBI Accession: NP_001034556, NP_005864

UniProt: P49795

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling