anti-MMP14 antibody (Matrix Metallopeptidase 14 (Membrane-inserted)) (AA 145-174)

Details for Product anti-MMP14 Antibody No. ABIN390138
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Antigen
Synonyms MMP-14, mmp-x1, mt1-mmp, mtmmp1, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1, AI325305, MT-MMP-1, sabe, Mt1-mmp, MMP1
Epitope
AA 145-174, N-Term
(47), (17), (16), (14), (12), (10), (6), (6), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(225), (54), (51), (2), (2), (2), (2), (1), (1), (1)
Host
Rabbit
(179), (38), (10), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
This MMP14 antibody is un-conjugated
(10), (10), (10), (7), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(191), (114), (62), (42), (20), (16), (14), (13), (10), (9), (8), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Immunogen This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 AA from the N-terminal region of human MMP14.
Clone RB02027
Isotype Ig
Specificity This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP14.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Pig (Porcine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MMP14 (MMP14 Antibody Abstract)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
Synonyms: Matrix metalloproteinase-14 [Precursor], MMP-14, EC 3.4.24.80, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP-X1, MMP14
Molecular Weight 65883 DA
Gene ID 4323
NCBI Accession NP_004986
Research Area Stem Cells, Protein Modifications, Cell Structure, Cancer
Application Notes WB = 1:1000, FACS = 1:10-50, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 145-174), (N-Term) antibody The anti-MMP14 N-term Antibody (ABIN390138) is used in Western blot to detect MMP14 i...
anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 145-174), (N-Term) antibody (2) Western blot analysis of MMP14 (arrow) using rabbit polyclonal MMP14 Antibody (N-term...
anti-Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14) (AA 145-174), (N-Term) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Zhu, Hong, Tripathi et al.: "Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells." in: Molecular cancer research : MCR, Vol. 11, Issue 1, pp. 86-94, 2013 (PubMed).

Background publications Sato, Takino, Okada et al.: "A matrix metalloproteinase expressed on the surface of invasive tumour cells." in: Nature, Vol. 370, Issue 6484, pp. 61-5, 1994 (PubMed).

Okada, Bellocq, Rouyer et al.: "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 7, pp. 2730-4, 1995 (PubMed).

Will, Hinzmann: "cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment." in: European journal of biochemistry / FEBS, Vol. 231, Issue 3, pp. 602-8, 1995 (PubMed).

Validation Images
Catalog No. ABIN390138
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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