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Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) (AA 154-183), (N-Term) antibody

Details for Product No. ABIN390140, Supplier: Log in to see
Antigen
  • MT3-MMP
  • Mt3mmp
  • Mt3-mmp
  • C8orf57
  • MMP-X2
  • MT-MMP2
  • MT-MMP3
Epitope
AA 154-183, N-Term
32
18
15
6
4
3
1
1
1
1
1
1
1
1
Reactivity
Human
99
30
29
2
2
2
1
1
1
Host
Rabbit
97
2
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
6
5
5
4
4
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
60
49
46
22
11
10
4
1
1
1
Supplier
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Immunogen This MMP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 AA from the N-terminal region of human MMP16.
Clone RB2031
Isotype Ig
Specificity This MMP16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human MMP16.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MMP16 (MMP16 Antibody Abstract)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene for MMP16 produces two transcripts, which encode a membrane-bound form and a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
Synonyms: MMP16
Molecular Weight 53kd Isoform. 69521 DA
Gene ID 4325
NCBI Accession NP_072086
Research Area Stem Cells, Cell Structure, Protein Modifications, Cancer
Pathways
Application Notes IHC (p) = 1:50-100, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) (AA 154-183), (N-Term) antibody (ABIN390140) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-Matrix Metallopeptidase 16 (Membrane-inserted) (MMP16) (AA 154-183), (N-Term) antibody (ABIN390140) MMP16 Antibody (E169) (ABIN390140) western blot analysis in MDA-MB435 cell line lysat...
Background publications Matsumoto, Katoh, Saito et al.: "Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA." in: Biochimica et biophysica acta, Vol. 1354, Issue 2, pp. 159-70, 1998 (PubMed).

Sato, Tanaka, Takino et al.: "Assignment of the human genes for membrane-type-1, -2, and -3 matrix metalloproteinases (MMP14, MMP15, and MMP16) to 14q12.2, 16q12.2-q21, and 8q21, respectively, by in situ hybridization." in: Genomics, Vol. 39, Issue 3, pp. 412-3, 1997 (PubMed).

Mattei, Roeckel, Olsen et al.: "Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively." in: Genomics, Vol. 40, Issue 1, pp. 168-9, 1997 (PubMed).