Matrix Metallopeptidase 25 (MMP25) (C-Term), (AA 470-499) antibody

Details for Product No. ABIN390146
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Antigen
Synonyms MMP20, MT6-MMP, Leukolysin, F730048C11Rik, MMP-25, MMP20A, MMPL1, MT-MMP 6, MT-MMP6, MT6MMP, MTMMP6
Epitope
C-Term, AA 470-499
(3), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(23), (2)
Host
Rabbit
(19), (4)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
(22), (8), (8), (3), (3), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN390146
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 AA from the C-terminal region of human MMP25.
Clone RB2043
Isotype Ig
Specificity This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MMP25.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name MMP25
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP25 is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. In addition, it is thought that this protein is activated intracellularly by furin-like enzymes. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP20 but has been renamed matrix metalloproteinase 25 (MMP25).
Molecular Weight 62554 DA
Gene ID 64386
UniProt NP_071913
Research Area Stem Cells, Protein Modifications, Cell Structure, Cancer
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Matrix Metallopeptidase 25 (MMP25) (C-Term), (AA 470-499) antibody The anti-MMP25 C-term Antibody (ABIN390146) is used in Western blot to detect MMP25 in mouse liver tissue lysate (lane 1) and HL60 cell lysate (lane 2) lysate.
Background publications Nagase, Woessner: "Matrix metalloproteinases." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21491-4, 1999 (PubMed).

Matsuda, Itoh, Koshikawa et al.: "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36350-7, 2003 (PubMed).

Hosts (19), (4)
Reactivities (23), (2)
Applications (22), (8), (8), (3), (3), (2), (2), (1)
Epitopes (3), (1), (1), (1), (1)
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