MMP25 antibody (AA 350-540)

Catalog No. ABIN7268422

This Rabbit Polyclonal antibody specifically detects MMP25 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for MMP25 antibody (AA 350-540) (ABIN7268422)

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP25 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MMP25 Antibody

Binding Specificity: AA 350-540

Purpose: MMP25 Rabbit pAb

Sequence: SPRPARLHRF WEGLPAQVRV VQAAYARHRD GRILLFSGPQ FWVFQDRQLE GGARPLTELG LPPGEEVDAV FSWPQNGKTY LVRGRQYWRY DEAAARPDPG YPRDLSLWEG APPSPDDVTV SNAGDTYFFK GAHYWRFPKN SIKTEPDAPQ PMGPNWLDCP APSSGPRAPR PPKATPVSET CDCQCELNQA A

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 350-540 of human MMP25 (NP_071913.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MMP25

Target: MMP25 (Matrix Metallopeptidase 25 (MMP25))

Alternative Name: MMP25

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.,MMP25,MMP-25,MMP20,MMP20A,MMPL1,MT-MMP 6,MT-MMP6,MT6-MMP,MT6MMP,MTMMP6,Cancer,Invasion and Metastasis,Signal Transduction,Cell Biology & Developmental Biology,Cytoskeleton,Extracellular Matrix,MMPs,Ubiquitin,MMP25

Molecular Weight: 62kDa

Gene ID: 64386

UniProt: Q9NPA2