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WNT1 Inducible Signaling Pathway Protein 2 (WISP2) (AA 87-116), (Center) antibody

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Synonyms MGC84196, WISP2, ccn5, CCN5, CT58, CTGF-L, Ccn5, Crgr4, Ctgfl, Rcop1
AA 87-116, Center
(13), (8), (7), (6), (6), (5), (4), (3), (2), (2), (1), (1), (1)
(69), (8), (4)
(62), (14)
Clonality (Clone)
Polyclonal ()
(9), (4), (2), (2), (2), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(61), (46), (15), (9), (8), (5), (4), (4), (2), (1), (1)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This WISP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 87-116 AA from the Central region of human WISP2.
Clone RB2114
Isotype Ig
Specificity This WISP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from between amino acids 100-130 of human WISP2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name WISP2 (WISP2 Antibody Abstract)
Background Wisp2 a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. Wisp2 lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Molecular Weight 26825 DA
Gene ID 8839
NCBI Accession NP_003872
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-WNT1 Inducible Signaling Pathway Protein 2 (WISP2) (AA 87-116), (Center) antibody (ABIN390188) Western blot analysis of anti-Wisp2 Ctr Pab (ABIN390188) in A549 cell lysate. Wisp2 (...
Immunohistochemistry (IHC) image for anti-WNT1 Inducible Signaling Pathway Protein 2 (WISP2) (AA 87-116), (Center) antibody (ABIN390188) WISP2 Antibody (Center) (ABIN390188)immunohistochemistry analysis in formalin fixed a...
Product cited in: Ji, Jia, Jia et al.: "WISP-2 in human gastric cancer and its potential metastatic suppressor role in gastric cancer cells mediated by JNK and PLC-? pathways." in: British journal of cancer, Vol. 113, Issue 6, pp. 921-33, 2015 (PubMed).

Background publications Kumar, Hand, Connor et al.: "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions." in: The Journal of biological chemistry, Vol. 274, Issue 24, pp. 17123-31, 1999 (PubMed).

Pennica, Swanson, Welsh et al.: "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 25, pp. 14717-22, 1999 (PubMed).

Catalog No. ABIN390188
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