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HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) (AA 431-461), (Center) antibody

Details for Product No. ABIN390223, Supplier: Login to see
Antigen
  • HIRA
  • wu:fb97b07
  • wu:fi43b08
  • si:ch211-188g24.3
  • AA138857
  • D16Ertd95e
  • N28177
  • Tuple1
  • DGCR1
  • TUP1
  • TUPLE1
  • dgcr1
  • hira-A
  • tup1
  • tuple1
  • homolog of histone chaperone HIRA
Epitope
AA 431-461, Center
18
15
6
4
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
55
14
2
1
Host
Rabbit
44
16
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Western Blotting (WB)
41
27
12
7
6
4
3
2
1
1
Supplier
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Immunogen This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 431-461 AA from the Central region of human HIRA.
Clone RB13843
Isotype Ig
Specificity This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 439~468 amino acids from the Center region of human HIRA.
Predicted Reactivity Chicken,Mouse (Murine),Xenopus laevis
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name HIRA (HIRA Antibody Abstract)
Background HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Synonyms: TUP1-like enhancer of split protein 1, DGCR1, HIR, TUPLE1
Molecular Weight 111835 DA
Gene ID 7290
UniProt P54198
Research Area Cell Cycle, Signaling, Chromatin, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae) (HIRA) (AA 431-461), (Center) antibody (ABIN390223) Western blot analysis of anti-HIRA Antibody (Center) (ABIN390223) in HL60 cell line l...
Background publications Zhang, Chen, Adams: "Molecular dissection of formation of senescence-associated heterochromatin foci." in: Molecular and cellular biology, Vol. 27, Issue 6, pp. 2343-58, 2007 (PubMed).