HIRA Products
(HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))
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This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008].
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Featured HIRA Categories
HIRA Antibodies
High quality antibodies with extensive validation data.
HIRA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HIRA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN6141776
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN7264499
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN1490946
Quantity
100 μL
Datasheet
Datasheet
Recommended HIRA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306658
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306657
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3092925
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our HIRA products
: "Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes." in: Nature structural & molecular biology, Vol. 21, Issue 7, pp. 609-16, (2014) (PubMed).: "HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a." in: PLoS ONE, Vol. 6, Issue 2, pp. e17036, (2011) (PubMed).
: "Molecular dissection of formation of senescence-associated heterochromatin foci." in: Molecular and cellular biology, Vol. 27, Issue 6, pp. 2343-58, (2007) (PubMed).
: "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly." in: Nature structural & molecular biology, Vol. 13, Issue 10, pp. 921-9, (2006) (PubMed).
: "Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression." in: Cell, Vol. 110, Issue 1, pp. 69-80, (2002) (PubMed).
: "Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation." in: The Journal of biological chemistry, Vol. 276, Issue 3, pp. 1808-13, (2001) (PubMed).
: "Ssn6-Tup1 interacts with class I histone deacetylases required for repression." in: Genes & development, Vol. 14, Issue 21, pp. 2737-44, (2000) (PubMed).
Synonyms and alternative names related to HIRA
histone cell cycle regulator (HIRA), histone cell cycle regulator a (hira), protein HIRA (LOC100052845), protein HIRA (LOC100352472), HIR histone cell cycle regulation defective homolog A (S. cerevisiae) (HIRA), protein HIRA (LOC100407742), protein HIRA (LOC100450459), protein HIRA (LOC100467668), protein HIRA (LOC100581135), protein HIRA (LOC486424), histone cell cycle regulator (Hira), HIRA (LOC732736), histone cell cycle regulator S homeolog (hira.S), histone chaperone HIRA-like protein (HIRA), Tuple1/HirA (hira), AA138857, D16Ertd95e, DGCR1, dgcr1, HIRA, hira-A, homolog of histone chaperone HIRA, N28177, si:ch211-188g24.3, TUP1, tup1, Tuple1, TUPLE1, tuple1, wu:fb97b07, wu:fi43b08Protein level used designations for HIRA
- HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
- fb97b07
- HIR histone cell cycle regulation defective homolog A-like
- protein HIRA-like
- histone cell cycle regulation defective homolog A
- protein HIRA
- TUP1-like enhancer of split protein 1
- cHIRA
- histone regulator protein
- TUP1-like enhancer of split gene 1
- DiGeorge critical region gene 1
- HIR histone cell cycle regulation defective homolog A
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