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Details for Product No. ABIN390383

Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) (N-Term), (AA 13-42) antibody

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Synonyms NOT, RNR1, HZF-3, NURR1, TINUR, Nurr1, RNR-1, TINOR, ngf1b, nr4a2, nurr1, zgc:92696, nr41/42/43, Nr4a2, not, rnr1, hzf-3, tinur, NGFI-B
»Alternatives N-Term, AA 13-42
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN390383
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13-42 AA from the N-terminal region of human NURR1 (NR4A2).
Clone RB7385
Isotype Ig
Specificity This NURR1 (NR4A2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20~50 amino acids from the N-terminal region of human NURR1 (NR4A2).
Predicted Reactivity Cow (Bovine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name NURR1 (NR4A2)
Background Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.
Synonyms: Orphan nuclear receptor NR4A2, Orphan nuclear receptor NURR1, NURR1, NGFI-B, TINUR, NR4A2, Immediate-early response protein NOT, NOT, Transcriptionally inducible nuclear receptor
Molecular Weight 66591 Da
Gene ID 4929
UniProt P43354
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Transcription Factors, Signaling, Neurology, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Okabe, Takayanagi, Imasaki et al.: "cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 8, pp. 3871-9, 1995 (PubMed).

Ichinose, Ohye, Suzuki et al.: "Molecular cloning of the human Nurr1 gene: characterization of the human gene and cDNAs." in: Gene, Vol. 230, Issue 2, pp. 233-9, 1999 (PubMed).

Alternatives for antigen "Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2)", type "Antibodies"
Hosts (42), (22)
Reactivities (62), (24), (23), (15), (14), (3), (3), (2), (1), (1)
Applications (50), (34), (10), (10), (10), (8), (3), (2), (1), (1), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1)