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Details for Product No. ABIN390885

Calreticulin (CALR) (AA 277-305), (Center) antibody

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Antigen
Synonyms
CRT, RO, SSA, cC1qR, Calregulin, CRP55, ERp60, HACBP, CALR, crc, crt, Crt, zgc:85636, CG9429, Clr, Dmel\\CG9429, anon-EST:Liang-2.11, anon-EST:Liang-2.17, anon-EST:fe3D7, clone 2.11, clone 2.17, eth,  ... show more
Epitope
»Alternatives AA 277-305, Center
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
Pubmed 1 reference available
Catalog no. ABIN390885
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This CALR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-305 AA from the Central region of human CALR.
Clone RB21112
Isotype Ig
Specificity This CALR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 284~313 amino acids from the Center region of human CALR.
Predicted Reactivity Monkey
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CALR
Background Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.
Synonyms: Calreticulin, CRP55, Calregulin, HACBP, ERp60, grp60, CRTC, CALR
Molecular Weight 48142 DA
Gene ID 811
UniProt P27797
Research Area Neurology
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Alur, Nguyen, Eggener et al.: "Suppressive roles of calreticulin in prostate cancer growth and metastasis." in: The American journal of pathology, Vol. 175, Issue 2, pp. 882-90, 2009 (PubMed).

Alternatives for antigen "Calreticulin (CALR)", type "Antibodies"
Hosts (84), (27), (6), (6), (6)
Reactivities (113), (62), (42), (29), (23), (22), (20), (12), (9), (9), (7), (7), (1), (1)
Applications (116), (38), (38), (35), (29), (26), (20), (11), (10), (7), (3), (2), (1), (1)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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