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Details for Product No. ABIN391014

Protein Kinase D3 (PRKD3) (AA 352-384) antibody

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Synonyms EPK2, PKD3, PRKCN, PKC-NU, nPKC-NU, 4930557O20Rik, 5730497N19Rik, Pkcnu, Prkcn, PRKD3
»Alternatives AA 352-384
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN391014
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This PKC-nu antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 352-384 AA from human PKC-nu.
Clone RB1047
Isotype Ig
Specificity This PKC nu antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 361~390 amino acids from the center region of human PKC nu.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PKC nu
Background Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. PKC nu is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members.
Synonyms: Protein kinase C, nu type, nPKC-nu, Protein kinase EPK2, PKD3
Molecular Weight 100470 Da
Gene ID 23683
UniProt O94806
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 1.2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Matthews, Dayalu, Thompson et al.: "Regulation of protein kinase Cnu by the B-cell antigen receptor." in: The Journal of biological chemistry, Vol. 278, Issue 11, pp. 9086-91, 2003 (PubMed).

Rey, Yuan, Young et al.: "Protein kinase C nu/protein kinase D3 nuclear localization, catalytic activation, and intracellular redistribution in response to G protein-coupled receptor agonists." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23773-85, 2003 (PubMed).

Yeaman, Ayala, Wright et al.: "Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network." in: Nature cell biology, Vol. 6, Issue 2, pp. 106-12, 2004 (PubMed).

Alternatives for antigen "Protein Kinase D3 (PRKD3)", type "Antibodies"
Hosts (59), (3), (1)
Reactivities (64), (32), (25), (24), (24), (12), (12), (12)
Applications (31), (22), (20), (17), (5), (5), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (12), (8), (4), (2), (2), (2), (1), (1), (1), (1)