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PRKD3 Products

(Protein Kinase D3 (PRKD3))

Categories

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq, Jul 2008].

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Featured PRKD3 Categories

PRKD3 Antibodies

High quality antibodies with extensive validation data.

PRKD3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PRKD3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (5)
Cat. No. ABIN3032380
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, WB
Validations
  • (4)
Cat. No. ABIN3032381
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN5014179
Quantity 100 μL
Datasheet Datasheet

Recommended PRKD3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (2)
Cat. No. ABIN5569954
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093512
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3136543
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PRKD3 products

Borges, Döppler, Perez, Andorfer, Sun, Anastasiadis, Thompson, Geiger, Storz: "Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis." in: Breast cancer research : BCR, Vol. 15, Issue 2, pp. R66, (2014) (PubMed).

Spratley, Bastea, Döppler, Mizuno, Storz: "Protein kinase D regulates cofilin activity through p21-activated kinase 4." in: The Journal of biological chemistry, Vol. 286, Issue 39, pp. 34254-61, (2011) (PubMed).

Azoitei, Pusapati, Kleger, Möller, Küfer, Genze, Wagner, van Lint, Carmeliet, Adler, Seufferlein: "Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours." in: Gut, Vol. 59, Issue 10, pp. 1316-30, (2010) (PubMed).

Chen, Li, Silva, Jackson, Zhou, Watanabe, Ives, Hellmich, Evers: "PKD3 is the predominant protein kinase D isoform in mouse exocrine pancreas and promotes hormone-induced amylase secretion." in: The Journal of biological chemistry, Vol. 284, Issue 4, pp. 2459-71, (2009) (PubMed).

Hao, Wang, Tang: "Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells." in: American journal of physiology. Cell physiology, Vol. 296, Issue 4, pp. C821-7, (2009) (PubMed).

Tan, Hao, Xu, Chisolm, Cui: "Lysophosphatidylcholine activates a novel PKD2-mediated signaling pathway that controls monocyte migration." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 9, pp. 1376-82, (2009) (PubMed).

Chen, Deng, Singh, Wang: "Protein kinase D3 (PKD3) contributes to prostate cancer cell growth and survival through a PKCepsilon/PKD3 pathway downstream of Akt and ERK 1/2." in: Cancer research, Vol. 68, Issue 10, pp. 3844-53, (2008) (PubMed).

Watkins, Lewandowski, Meek, Storz, Toker, Piwnica-Worms: "Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18378-83, (2008) (PubMed).

Storz, Döppler, Toker: "Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species." in: Molecular and cellular biology, Vol. 25, Issue 19, pp. 8520-30, (2005) (PubMed).

Zhang, Zheng, Storz, Min: "Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor." in: The Journal of biological chemistry, Vol. 280, Issue 19, pp. 19036-44, (2005) (PubMed).

Synonyms and alternative names related to PRKD3

protein kinase D3 (PRKD3), protein kinase D3 (prkd3), protein kinase D3 (Prkd3), 4930557O20Rik, 5730497N19Rik, EPK2, nPKC-NU, PKC-NU, Pkcnu, PKD3, PRKCN, Prkcn, PRKD3

Protein level used designations for PRKD3

  • protein kinase C nu type
  • protein kinase C, nu
  • protein kinase EPK2
  • protein-serine/threonine kinase
  • serine/threonine-protein kinase D3
  • protein kinase D3
  • serine/threonine-protein kinase D3-like
  • nPKC-nu
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