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Details for Product No. ABIN391160

Activin A Receptor, Type IIA (ACVR2A) (N-Term), (AA 2-29) antibody

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Antigen
Synonyms ACVR2, ACTRII, Acvr2, ActrIIa, TactrII, rActR-II, XSTK9, actrii, acvr2, actr2a, acvr2a, wu:fa02e10, ACVR2A
Epitope
»Alternatives N-Term, AA 2-29
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN391160
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 AA from the N-terminal region of human ACVR2A.
Clone RB08169-08170
Isotype Ig
Specificity This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACVR2A
Background ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Synonyms: Activin receptor type-2A [Precursor], Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2
Molecular Weight 57639 DA
Gene ID 92
UniProt P27037
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).

Greenwald, Groppe, Gray et al.: "The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly." in: Molecular cell, Vol. 11, Issue 3, pp. 605-17, 2003 (PubMed).

Olaru, Mori, Yin et al.: "Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 12, pp. 1867-71, 2003 (PubMed).

Alternatives for antigen "Activin A Receptor, Type IIA (ACVR2A)", type "Antibodies"
Hosts (29), (7), (5)
Reactivities (33), (16), (8), (2), (1), (1), (1), (1), (1), (1)
Applications (40), (21), (12), (10), (5), (3), (2), (2)
Conjugates (3), (1)
Epitopes (13), (4), (2), (1), (1), (1), (1), (1), (1)
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