Activin A Receptor, Type IIA (ACVR2A) (N-Term), (AA 2-29) antibody

Details for Product No. ABIN391160
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Antigen
Synonyms ACVR2, ACVR2A, XSTK9, actrii, acvr2, ACTRII, Acvr2, rActR-II, actr2a, acvr2a, wu:fa02e10, ActrIIa, TactrII
Epitope
N-Term, AA 2-29
(17), (7), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(41), (21), (8), (3), (1), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(49), (6), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(53), (34), (13), (13), (8), (6), (4), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN391160
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Immunogen This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 AA from the N-terminal region of human ACVR2A.
Clone RB08169-08170
Isotype Ig
Specificity This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR2A.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ACVR2A
Background ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
Synonyms: Activin receptor type-2A [Precursor], Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2
Molecular Weight 57639 DA
Gene ID 92
UniProt P27037
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Activin A Receptor, Type IIA (ACVR2A) (N-Term), (AA 2-29) antibody Western blot analysis of anti-ACVR2A Antibody (N-term) (ABIN391160) in mouse liver brain and kidney tissue lysates (35 µg/lane). ACVR2A (arrow) was detected using the purified polyclonal antibody.
anti-Activin A Receptor, Type IIA (ACVR2A) (N-Term), (AA 2-29) antibody (2) Western blot analysis of ACVR2A (arrow) using rabbit polyclonal ACVR2A Antibody (N-term) (ABIN391160). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR2A gene (Lane 2) (Origene Technologies).
anti-Activin A Receptor, Type IIA (ACVR2A) (N-Term), (AA 2-29) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Casagrandi, Bearfield, Geary et al.: "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia." in: Molecular human reproduction, Vol. 9, Issue 4, pp. 199-203, 2003 (PubMed).

Greenwald, Groppe, Gray et al.: "The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly." in: Molecular cell, Vol. 11, Issue 3, pp. 605-17, 2003 (PubMed).

Olaru, Mori, Yin et al.: "Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 83, Issue 12, pp. 1867-71, 2003 (PubMed).

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