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Details for Product No. ABIN391349

Sphingosine Kinase 2 (SPHK2) (C-Term), (AA 590-620) antibody

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Antigen
Synonyms SK 2, SK-2, SPK 2, SPK-2, C76851, CG2159, CG32484, Dmel\\CG32484, SK2, Sphk2, sk2, DKFZp469F224
Epitope
»Alternatives C-Term, AA 590-620
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN391349
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-620 AA from the C-terminal region of human SPHK2.
Clone RB03625
Isotype Ig
Specificity This SPHK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 598~627 amino acids from the C-terminal region of human SPHK2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name SPHK2
Background Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
Synonyms: Sphingosine kinase 2, SK 2, SPK 2
UniProt Q9NRA0
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cancer, Cell Cycle
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C.
Expiry Date 6 months
Background publications Shutler, Glassco, Kang et al.: "Genomic structure of the human D-site binding protein (DBP) gene." in: Genomics, Vol. 34, Issue 3, pp. 334-9, 1996 (PubMed).

Liu, Sugiura, Nava et al.: "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform." in: The Journal of biological chemistry, Vol. 275, Issue 26, pp. 19513-20, 2000 (PubMed).

Alternatives for antigen "Sphingosine Kinase 2 (SPHK2)", type "Antibodies"
Hosts (60), (1)
Reactivities (60), (36), (26)
Applications (38), (29), (19), (14), (14), (2), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (9), (6), (5), (3), (2), (2), (1), (1)
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