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SPHK2 antibody (AA 1-30)

SPHK2 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3032712
  • Target See all SPHK2 Antibodies
    SPHK2 (Sphingosine Kinase 2 (SPHK2))
    Binding Specificity
    • 15
    • 12
    • 10
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-30
    Reactivity
    • 64
    • 27
    • 25
    Human
    Host
    • 61
    • 3
    Rabbit
    Clonality
    • 63
    • 1
    Polyclonal
    Conjugate
    • 34
    • 4
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SPHK2 antibody is un-conjugated
    Application
    • 43
    • 35
    • 31
    • 13
    • 13
    • 10
    • 4
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Purification
    Purified
    Immunogen
    A portion of amino acids 1-30 from the human protein was used as the immunogen for this SPHK2 antibody.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SPHK2 Primary Antibody
  • Application Notes
    Titration of the SPHK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Aliquot the SPHK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • Target
    SPHK2 (Sphingosine Kinase 2 (SPHK2))
    Alternative Name
    SPHK2 (SPHK2 Products)
    Synonyms
    CG2159 antibody, CG32484 antibody, Dmel\\CG32484 antibody, SK2 antibody, Sphk2 antibody, sk2 antibody, DKFZp469F224 antibody, SK 2 antibody, SK-2 antibody, SPK 2 antibody, SPK-2 antibody, C76851 antibody, Sphingosine kinase antibody, sphk2 antibody, Sphingosine kinase 2 antibody, sphingosine kinase 2 antibody, sphK2 antibody, Sk2 antibody, SPHK2 antibody, Sphk2 antibody
    Background
    Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.
    UniProt
    Q9NRA0
    Pathways
    VEGF Signaling
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