Carbonic Anhydrase IV (CA4) (C-Term), (AA 243-272) antibody

Details for Product No. ABIN391691
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Antigen
Synonyms caiv, car4, rp17, CA4, ca4, AW456718, Ca4, CAIV, Car4, RP17
Epitope
C-Term, AA 243-272
(5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(28), (7), (2), (1), (1)
Host
Rabbit
(27), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1)
Application
Western Blotting (WB)
(27), (12), (11), (5), (4), (2), (2), (1), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN391691
291.50 $
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Immunogen This CA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 AA from the C-terminal region of human CA4.
Clone RB18373
Isotype Ig
Specificity This CA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250~279 amino acids from the C-terminal region of human CA4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CA4
Background CA4 is a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This protein is a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known, however, the protein may have a role in inherited renal abnormalities of bicarbonate transport.
Synonyms: Carbonic anhydrase 4, Carbonic anhydrase IV, CA-IV, Carbonate dehydratase IV , CA4
Molecular Weight 35032 DA
Gene ID 762
UniProt P22748
Research Area Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Carbonic Anhydrase IV (CA4) (C-Term), (AA 243-272) antibody Western blot analysis of CA4 Antibody (C-term) (ABIN391691) in mouse lung tissue lysates (35 µg/lane). CA4 (arrow) was detected using the purified polyclonal antibody.
Background publications Okuyama, Sato, Zhu et al.: "Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 4, pp. 1315-9, 1992 (PubMed).

Okuyama, Batanian, Sly: "Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q." in: Genomics, Vol. 16, Issue 3, pp. 678-84, 1993 (PubMed).

Yang, Alvarez, Chakarova et al.: "Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration." in: Human molecular genetics, Vol. 14, Issue 2, pp. 255-65, 2004 (PubMed).

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