Mitogen-Activated Protein Kinase 7 (MAPK7) (C-Term), (AA 776-805) antibody

Details for Product No. ABIN391722
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Antigen
Synonyms A330097D03Rik, Erk3, Prkm4, p63Mapk, BMK1, ERK4, ERK5, PRKM7, Erk5-T, Bmk1, Erk5, Prkm7, ERK-5, ATMPK7, F8D23.5, F8D23_5, MAP kinase 7
Epitope
C-Term, AA 776-805
(18), (18), (17), (13), (13), (13), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(123), (77), (72), (48), (47), (24), (12)
Host
Rabbit
(107), (13), (2), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(72), (49), (21), (19), (15), (11), (10), (4), (3), (3)
Pubmed 2 references available
Quantity 400 µL
Options
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Catalog No. ABIN391722
291.50 $
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Immunogen This MAPK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 776-805 AA from the C-terminal region of human MAPK7.
Clone RB0919
Isotype Ig
Specificity This ERK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782~812 amino acids from the C-terminal region of human ERK5.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ERK5
Background MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
Synonyms: Extracellular signal-regulated kinase 5, Mitogen-activated protein kinase 7
Molecular Weight 88636 DA
Gene ID 5598
UniProt Q13164
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase 7 (MAPK7) (C-Term), (AA 776-805) antibody Western blot analysis of anti-ERK5 C-term Pab (ABIN391722) in K562 cell line lysates (35 µg/lane). ERK5 (arrow) was detected using the purified polyclonal antibody.
anti-Mitogen-Activated Protein Kinase 7 (MAPK7) (C-Term), (AA 776-805) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
anti-Mitogen-Activated Protein Kinase 7 (MAPK7) (C-Term), (AA 776-805) antibody (3) Formalin-fixed and paraffin-embedded human kideny carcinoma tissue reacted with ERK5 Antibody (C-term) (ABIN391722), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Lee, Ulevitch, Han: "Primary structure of BMK1: a new mammalian map kinase." in: Biochemical and biophysical research communications, Vol. 213, Issue 2, pp. 715-24, 1995 (PubMed).

Zhou, Bao, Dixon: "Components of a new human protein kinase signal transduction pathway." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12665-9, 1995 (PubMed).

Validation Images
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