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Cyclin-Dependent Kinase 10 (CDK10) (AA 1-32), (N-Term) antibody

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Antigen
Synonyms zgc:110252, DDBDRAFT_0216532, DDBDRAFT_0229427, DDB_0216532, DDB_0229427, cdc2rk, NV16107, PISSLRE, BC017131
Epitope
AA 1-32, N-Term
(27), (15), (15), (14), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(79), (29), (26), (2), (1), (1)
Host
Rabbit
(68), (12), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(68), (50), (24), (11), (5), (1), (1), (1)
Pubmed 11 references available
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Quantity 400 μL
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Immunogen This CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-32 AA from the N-terminal region of human CDK10.
Clone RB3172
Isotype Ig
Specificity This CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~44 amino acids from the N-terminal region of human CDK10.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDK10 (CDK10 Antibody Abstract)
Background CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
Synonyms: Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE
Molecular Weight 41038 DA
Gene ID 8558
UniProt Q15131
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Cyclin-Dependent Kinase 10 (CDK10) (AA 1-32), (N-Term) antibody (ABIN391741) Western blot analysis of CDK10 antibody (N-term) (ABIN391741) pre-incubated with (Lan...
Immunohistochemistry (IHC) image for anti-Cyclin-Dependent Kinase 10 (CDK10) (AA 1-32), (N-Term) antibody (ABIN391741) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: You, Li, Qin et al.: "Decreased CDK10 expression correlates with lymph node metastasis and predicts poor outcome in breast cancer patients - a short report." in: Cellular oncology (Dordrecht), Vol. 38, Issue 6, pp. 485-91, 2015 (PubMed).

Hong, Zhang, You et al.: "Elevated C1orf63 expression is correlated with CDK10 and predicts better outcome for advanced breast cancers: a retrospective study." in: BMC cancer, Vol. 15, pp. 548, 2015 (PubMed).

Leman, Magheli, Yong et al.: "Identification of nuclear structural protein alterations associated with seminomas." in: Journal of cellular biochemistry, Vol. 108, Issue 6, pp. 1274-9, 2009 (PubMed).

Background publications Ganoth, Bornstein, Ko et al.: "The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27." in: Nature cell biology, Vol. 3, Issue 3, pp. 321-4, 2001 (PubMed).

Crawford, Ianzano, Savino et al.: "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer." in: Genomics, Vol. 56, Issue 1, pp. 90-7, 1999 (PubMed).

Morgan: "Cyclin-dependent kinases: engines, clocks, and microprocessors." in: Annual review of cell and developmental biology, Vol. 13, pp. 261-91, 1998 (PubMed).

Sherr: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, 1997 (PubMed).

Parge, Arvai, Murtari et al.: "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control." in: Science (New York, N.Y.), Vol. 262, Issue 5132, pp. 387-95, 1993 (PubMed).

Graña, Claudio, De Luca et al.: "PISSLRE, a human novel CDC2-related protein kinase." in: Oncogene, Vol. 9, Issue 7, pp. 2097-103, 1994 (PubMed).

Brambilla, Draetta: "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases." in: Oncogene, Vol. 9, Issue 10, pp. 3037-41, 1994 (PubMed).

Hershko, Ciechanover: "The ubiquitin system for protein degradation." in: Annual review of biochemistry, Vol. 61, pp. 761-807, 1992 (PubMed).

Catalog No. ABIN391741
$324.50
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