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Cyclin-Dependent Kinase 10 (CDK10) (N-Term), (AA 1-32) antibody

Details for Product No. ABIN391741
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Antigen
Epitope
N-Term, AA 1-32
(10), (7), (6), (6), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(51), (22), (21), (12), (12), (12), (12)
Host
Rabbit
(48), (3), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(43), (31), (14), (10), (6), (1)
Pubmed 9 references available
Quantity 400 µL
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Catalog No. ABIN391741
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen This CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-32 AA from the N-terminal region of human CDK10.
Clone RB3172
Isotype Ig
Specificity This CDK10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~44 amino acids from the N-terminal region of human CDK10.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDK10
Background CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase.
Synonyms: Cell division protein kinase 10, Serine/threonine-protein kinase PISSLRE
Molecular Weight 41038 DA
Gene ID 8558
UniProt Q15131
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase 10 (CDK10) (N-Term), (AA 1-32) antibody Western blot analysis of CDK10 antibody (N-term) (ABIN391741) pre-incubated with (Lane1) and without (Lane 2) blocking peptide (BP7516a) in A375 cell line lysate. CDK10 (arrow) was detected using the purified polyclonal antibody.
anti-Cyclin-Dependent Kinase 10 (CDK10) (N-Term), (AA 1-32) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Hershko, Ciechanover: "The ubiquitin system for protein degradation." in: Annual review of biochemistry, Vol. 61, pp. 761-807, 1992 (PubMed).

Brambilla, Draetta: "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases." in: Oncogene, Vol. 9, Issue 10, pp. 3037-41, 1994 (PubMed).

Graña, Claudio, De Luca et al.: "PISSLRE, a human novel CDC2-related protein kinase." in: Oncogene, Vol. 9, Issue 7, pp. 2097-103, 1994 (PubMed).

Parge, Arvai, Murtari et al.: "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control." in: Science (New York, N.Y.), Vol. 262, Issue 5132, pp. 387-95, 1993 (PubMed).

Sherr: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, 1997 (PubMed).

Morgan: "Cyclin-dependent kinases: engines, clocks, and microprocessors." in: Annual review of cell and developmental biology, Vol. 13, pp. 261-91, 1998 (PubMed).

Crawford, Ianzano, Savino et al.: "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer." in: Genomics, Vol. 56, Issue 1, pp. 90-7, 1999 (PubMed).

Ganoth, Bornstein, Ko et al.: "The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27." in: Nature cell biology, Vol. 3, Issue 3, pp. 321-4, 2001 (PubMed).

General Leman, Magheli, Yong et al.: "Identification of nuclear structural protein alterations associated with seminomas." in: Journal of cellular biochemistry, Vol. 108, Issue 6, pp. 1274-9, 2009 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN391741
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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