Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) (C-Term), (AA 183-212) antibody

Details for Product No. ABIN391764
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Antigen
Synonyms CDKN3, CDI1, CIP2, KAP, KAP1, 2410006H10Rik
Epitope
C-Term, AA 183-212
(12), (9), (8), (7), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(83), (24), (18), (13), (13), (13), (12)
Host
Rabbit
(57), (27)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(75), (27), (21), (17), (10), (10), (10), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN391764
291.50 $
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Immunogen This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 AA from the C-terminal region of human CDKN3.
Clone RB3225
Isotype Ig
Specificity This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~212 amino acids from the C-terminal region of human CDKN3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CDKN3
Background CDKN3 belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. The gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.
Synonyms: Cyclin-dependent kinase inhibitor 3, CDK2-associated dual specificity phosphatase, Kinase associated phosphatase, Cyclin-dependent kinase interacting protein 2, Cyclin-dependent kinase interactor 1
Molecular Weight 23805 DA
Gene ID 1033
UniProt Q16667
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) (C-Term), (AA 183-212) antibody Western blot analysis of anti-CDKN3 Pab (ABIN391764) in HL-60 cell lysate. CDKN3 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
anti-Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) (C-Term), (AA 183-212) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Poon, Hunter: "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin." in: Science (New York, N.Y.), Vol. 270, Issue 5233, pp. 90-3, 1995 (PubMed).

Hannon, Casso, Beach: "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1731-5, 1994 (PubMed).

Lee, Reimer, Fang et al.: "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1723-32, 2000 (PubMed).

Yeh, Lu, Chen et al.: "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma." in: Cancer research, Vol. 60, Issue 17, pp. 4697-700, 2000 (PubMed).

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