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Details for Product No. ABIN392048

Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R) (N-Term), (C-Term), (AA 22-51) antibody

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Antigen
Synonyms RON, PTK8, CD136, CDw136, Fv2, Ron, STK, Fv-2, Stk, Ptk8, Cdw136
Epitope
»Alternatives N-Term, C-Term, AA 22-51
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN392048
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This RON antibody is generated from rabbits immunized with two KLH conjugated synthetic peptides between 22-51 amino and 1370-1400 acids from the N-terminal and C-terminal regions of human RON.
Clone RB1356
Isotype Ig
Specificity This RON antibody is generated from rabbits immunized with two KLH conjugated synthetic peptides between 22~51 amino acids from the N-terminal and C-terminal regions of human RON.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name RON
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Synonyms: p185-Ron, CDW136, CD136 antigen, MST1R, RON, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, Macrophage-stimulating protein receptor MSPR, MSP receptor
Molecular Weight 152227 DA
Gene ID 4486
UniProt Q04912
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 1.64 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Zhou, He, Chen et al.: "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential." in: Oncogene, Vol. 22, Issue 2, pp. 186-97, 2003 (PubMed).

Danilkovitch-Miagkova, Duh, Kuzmin et al.: "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 8, pp. 4580-5, 2003 (PubMed).

Penengo, Rubin, Yarden et al.: "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor." in: Oncogene, Vol. 22, Issue 24, pp. 3669-79, 2003 (PubMed).

Alternatives for antigen "Macrophage Stimulating 1 Receptor (C-Met-Related tyrosine Kinase) (MST1R)", type "Antibodies"
Hosts (135), (14), (2)
Reactivities (124), (92), (64), (11), (11)
Applications (55), (50), (49), (46), (35), (9), (7), (5), (5), (2), (2), (1)
Conjugates (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (1)
Epitopes (34), (17), (17), (11), (10), (7), (6), (5), (5), (2), (2), (2), (1), (1)
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