Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 290-320), (Tyr10) antibody

Details for Product No. ABIN392068
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Antigen
Synonyms DDR2, ddr2, si:ch211-193c2.1, AW495251, Ntrkr3, tyro10, MIG20a, NTRKR3, TKT, TYRO10, Tyro10
Epitope
AA 290-320, Tyr10
(8), (8), (7), (4), (3), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(50), (25), (12), (12), (12), (12), (12)
Host
Rabbit
(45), (17)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (30), (19), (11), (10), (10), (4), (4), (3), (1)
Pubmed 5 references available
Quantity 400 μL
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Catalog No. ABIN392068
291.50 $
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Immunogen This DDR2 (TYRO10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-320 AA from human DDR2 (TYRO10).
Clone RB01473
Isotype Ig
Specificity This DDR2 (TYRO10) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297~327 amino acids from aa 304~320 of human TYRO10.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DDR2 (TYRO10)
Background Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.
Synonyms: Tyrosine-protein kinase TYRO 10, Discoidin domain receptor 2, Receptor protein-tyrosine kinase TKT, Neurotrophic tyrosine kinase, receptor-related 3, DDR2, NTRKR3, TKT
Molecular Weight 96752 DA
Gene ID 4921
UniProt Q16832
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle, Metabolism
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 290-320), (Tyr10) antibody Western blot analysis of anti-TYRO10 Pab (ABIN392068) in HL60 cell lysate. TYRO10 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Background publications Lapsys, Layfield, Baker et al.: "Chromosomal location of the human transketolase gene." in: Cytogenetics and cell genetics, Vol. 61, Issue 4, pp. 274-5, 1993 (PubMed).

Abedinia, Layfield, Jones et al.: "Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase." in: Biochemical and biophysical research communications, Vol. 183, Issue 3, pp. 1159-66, 1992 (PubMed).

Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995 (PubMed).

Karn, Holtrich, Bräuninger et al.: "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain." in: Oncogene, Vol. 8, Issue 12, pp. 3433-40, 1993 (PubMed).

Vogel, Gish, Alves et al.: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998 (PubMed).

Validation Images
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