Testis-Specific Kinase 2 (TESK2) (AA 210-240), (Center), (Cys225) antibody

Details for Product No. ABIN392278
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Antigen
Epitope
AA 210-240, Center, Cys225
(14), (10), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(60), (23), (23), (12)
Host
Rabbit
(42), (18)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(51), (34), (10), (10), (9), (8), (6), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN392278
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Immunogen This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-240 AA from the Central region of human TESK2.
Clone RB12617
Isotype Ig
Specificity This TESK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218~247 amino acids from the Center(C225) region of human TESK2.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name TESK2
Background TESK2 is a dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. TESK2 phosphorylates cofilin at Ser-3. It may play an important role in spermatogenesis. This nuclear enzyme is thought to be activated by autophosphorylation on Ser-219. Expression is predominantly in testis and prostate, with highest concentrations in nongerminal Sertoli cells.
Synonyms: Testicular protein kinase 2
Molecular Weight 63509 DA
Gene ID 10420
UniProt Q96S53
Research Area Apoptosis/Necrosis, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Testis-Specific Kinase 2 (TESK2) (AA 210-240), (Center), (Cys225) antibody Western blot analysis of anti-TESK2 Antibody (Center) (ABIN392278) in HL60 cell line lysates (35 µg/lane). TESK2 (arrow) was detected using the purified polyclonal antibody (1:60 dilution).
anti-Testis-Specific Kinase 2 (TESK2) (AA 210-240), (Center), (Cys225) antibody (2) Formalin-fixed and paraffin-embedded human testis tissue reacted with TESK2 antibody (Center)(ABIN392278), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Røsok, Pedeutour, Ree et al.: "Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis." in: Genomics, Vol. 61, Issue 1, pp. 44-54, 1999 (PubMed).

Toshima, Toshima, Takeuchi et al.: "Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 31449-58, 2001 (PubMed).

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