U2AF Homology Motif (UHM) Kinase 1 (UHMK1) (AA 1-30), (N-Term) antibody

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Synonyms UHMK1, zgc:153241, KIS, KIST, P-CIP2, 4732477C12Rik, 4930500M09Rik, AA673513, AI449218, AU021979, Kist
AA 1-30, N-Term
(31), (30), (15), (3), (2), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(67), (41), (20), (4), (3), (1), (1), (1)
(58), (14), (13)
Clonality (Clone)
Polyclonal ()
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(60), (42), (21), (10), (7), (6), (6), (2), (2), (1)
Pubmed 8 references available
Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human KIST (KIS).
Clone RB3367
Isotype Ig
Specificity This KIS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human KIS.
Predicted Reactivity Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name KIST (KIS) (UHMK1 Antibody Abstract)
Background Upon serum stimulation, KIS, a member of the Ser/Thr protein kinase family, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. This protein, which contains 1 RRM (RNA recognition motif)domain, may be involved in trafficking and/or processing of RNA. KIS is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.
Synonyms: Serine/threonine-protein kinase Kist, Kinase interacting with stathmin, U2AF homology motif kinase 1, UHMK1
Molecular Weight 46546 DA
Gene ID 127933
UniProt Q8TAS1
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-U2AF Homology Motif (UHM) Kinase 1 (UHMK1) (AA 1-30), (N-Term) antibody (ABIN392641) Western blot analysis of anti-KIS Pab (ABIN392641) in mouse heart tissue lysate. KIS ...
Immunohistochemistry (IHC) image for anti-U2AF Homology Motif (UHM) Kinase 1 (UHMK1) (AA 1-30), (N-Term) antibody (ABIN392641) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-U2AF Homology Motif (UHM) Kinase 1 (UHMK1) (AA 1-30), (N-Term) antibody (ABIN392641) KIS Antibody (C6) (ABIN392641) western blot analysis in A549 cell line lysates (35 µg...
Product cited in: Chen, Xie, Gu et al.: "Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation." in: Scientific reports, Vol. 5, pp. 8293, 2015 (PubMed).

Nakamura, Hirano, Okinaka et al.: "The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia." in: Carcinogenesis, Vol. 31, Issue 11, pp. 2012-21, 2010 (PubMed).

Lee, Kay: "PI 3-kinase/Rac1 and ERK1/2 regulate FGF-2-mediated cell proliferation through phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2." in: Investigative ophthalmology & visual science, Vol. 52, Issue 1, pp. 417-26, 2011 (PubMed).

Takemura, Nakamura, Yokota et al.: "Reduction of Raf kinase inhibitor protein expression by Bcr-Abl contributes to chronic myelogenous leukemia proliferation." in: The Journal of biological chemistry, Vol. 285, Issue 9, pp. 6585-94, 2010 (PubMed).

Nakamura, Yamashita, Yokota et al.: "Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity." in: Investigational new drugs, Vol. 28, Issue 4, pp. 381-91, 2010 (PubMed).

Petrovic, Costa, Lau et al.: "FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression." in: The Journal of biological chemistry, Vol. 283, Issue 1, pp. 453-60, 2007 (PubMed).

Background publications Bièche, Manceau, Curmi et al.: "Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human." in: Brain research. Molecular brain research, Vol. 114, Issue 1, pp. 55-64, 2003 (PubMed).

Boehm, Yoshimoto, Crook et al.: "A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression." in: The EMBO journal, Vol. 21, Issue 13, pp. 3390-401, 2002 (PubMed).

Catalog No. ABIN392641
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