UHMK1 antibody (C-Term)

Catalog No. ABIN6243411

The Rabbit Polyclonal anti-UHMK1 antibody is suitable to detect UHMK1 in samples from Human and Mouse. It has been validated for WB.

Quick Overview for UHMK1 antibody (C-Term) (ABIN6243411)

Target: UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UHMK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5431

Product Details anti-UHMK1 Antibody

Binding Specificity: AA 265-295, C-Term

Predicted Reactivity: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KIST (KIS) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-295 amino acids from the C-terminal region of human KIST (KIS).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for UHMK1

Target: UHMK1 (U2AF Homology Motif (UHM) Kinase 1 (UHMK1))

Alternative Name: KIST (KIS)

Background: KIST, a member of the Ser/Thr protein kinase family, is a pyruvate kinase that catalyzes formation of phosphoenolpyruvate from pyruvate and ATP. A role for the primarily nuclear KIST protein in mediation of cellular metabolism has been postulated based on the interaction identified with thyroid hormone. KIST is widely expressed, with highest abundance in skeletal muscle, kidney, placenta and peripheral blood leukocytes. Upon serum stimulation, KIST phosphorylates CDKN1B/p27Kip1, thereby regulating the subcellular location of CDKN1B and cell cycle progression in the G1 phase. KIST, which contains one RNA recognition motif domain, has been proposed to partipate in trafficking and processing of RNA. KIST binds to Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells.

Molecular Weight: 46546

NCBI Accession: NP_001171692, NP_653225, NP_787062

UniProt: Q8TAS1