PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody

Details for Product No. ABIN400795
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Antigen
Synonyms HNPCC4, PMS2CL, PMSL2, AW555130, Pmsl2
Epitope
AA 58-81
(9), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Chimpanzee, Hamster, Human, Mouse (Murine), Rat (Rattus)
(57), (6), (5), (1), (1)
Host
Mouse
(41), (17)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2)
Application
ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(37), (31), (11), (11), (9), (3), (2), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN400795
390.50 $
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Immunogen Recombinant human PMS2 corresponding to the first 133 amino acid residues of theprotein
Clone 349-29-5-2
Isotype IgG1
Characteristics Synonyms: PMSL2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2
Purification Protein chromatography
Alternative Name PMS2
Background PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNAreplication and hasbeen identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of theBRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2,MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Thisassociation could be a dynamic process changing throughout the cell cycle and withinsubnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectalcancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterizedby malignant tumors of the brain associated with multiple colorectal adenomas) andsupratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). Thehuman PMS2 gene encodes an 862 aa, 96 kDa polypeptide.
UniProt P54278
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes ELISA: 1: 5,000 - 1: 20,000. Western blot: 1: 500 - 1: 2,000. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.38 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 a buffer and 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody (2) anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody (Image 2)
Background publications Zankl, Schwanitz, Schmid et al.: "Distal 2q duplication: report of two familial cases and an attempt to define a syndrome." in: American journal of medical genetics, Vol. 4, Issue 1, pp. 5-16, 1979 (PubMed).

Nicolaides, Papadopoulos, Liu et al.: "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer." in: Nature, Vol. 371, Issue 6492, pp. 75-80, 1994 (PubMed).

Wang, Cortez, Yazdi et al.: "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures." in: Genes & development, Vol. 14, Issue 8, pp. 927-39, 2000 (PubMed).

Yuan, Gottlieb, Beitel et al.: "Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms." in: Human mutation, Vol. 19, Issue 2, pp. 108-13, 2002 (PubMed).

de Jong, van Puijenbroek, Hendriks et al.: "Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 3, pp. 972-80, 2004 (PubMed).

Luo, Lin, Lin: "ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage." in: Molecular and cellular biology, Vol. 24, Issue 14, pp. 6430-44, 2004 (PubMed).

Nakagawa, Lockman, Frankel et al.: "Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation." in: Cancer research, Vol. 64, Issue 14, pp. 4721-7, 2004 (PubMed).

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