PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody

Details for Product No. ABIN400795
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Synonyms PMSL2, HNPCC4, PMS2CL, AW555130, Pmsl2
AA 58-81
(8), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Chimpanzee, Hamster, Human, Mouse (Murine), Rat (Rattus)
(53), (7), (5), (1), (1)
(37), (18)
Clonality (Clone)
Monoclonal ()
ELISA, Immunoprecipitation (IP), Western Blotting (WB)
(36), (29), (12), (9), (7), (2), (2), (1)
Pubmed 7 references available
Catalog no. ABIN400795
Quantity 0.1 mg
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Immunogen Recombinant human PMS2 corresponding to the first 133 amino acid residues of theprotein
Clone 349-29-5-2
Isotype IgG1
Characteristics Synonyms: PMSL2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2
Purification Protein chromatography
Alternative Name PMS2
Background PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNAreplication and hasbeen identified to be composed as a heterodimer of PMS2 and MLH1. PMS is part of theBRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2,MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. Thisassociation could be a dynamic process changing throughout the cell cycle and withinsubnuclear domains. Defects in PMS2 are the cause of hereditary non-polyposis colorectalcancer type 4 (HNPCC4), Turcot syndrome (an autosomal dominant disorder characterizedby malignant tumors of the brain associated with multiple colorectal adenomas) andsupratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL). Thehuman PMS2 gene encodes an 862 aa, 96 kDa polypeptide.
UniProt P54278
Research Area Chromatin and Nuclear Signaling, DNA/RNA
Application Notes ELISA: 1: 5,000 - 1: 20,000. Western blot: 1: 500 - 1: 2,000. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.38 mg/mL (by UV absorbance at 280 nm)
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 a buffer and 0.09% (w/v) Sodium Azide as preservative
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody
anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody (2) anti-PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) (AA 58-81) antibody (Image 2)
Background publications Zankl, Schwanitz, Schmid et al.: "Distal 2q duplication: report of two familial cases and an attempt to define a syndrome." in: American journal of medical genetics, Vol. 4, Issue 1, pp. 5-16, 1979 (PubMed).

Nicolaides, Papadopoulos, Liu et al.: "Mutations of two PMS homologues in hereditary nonpolyposis colon cancer." in: Nature, Vol. 371, Issue 6492, pp. 75-80, 1994 (PubMed).

Wang, Cortez, Yazdi et al.: "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures." in: Genes & development, Vol. 14, Issue 8, pp. 927-39, 2000 (PubMed).

Yuan, Gottlieb, Beitel et al.: "Polymorphisms and HNPCC: PMS2-MLH1 protein interactions diminished by single nucleotide polymorphisms." in: Human mutation, Vol. 19, Issue 2, pp. 108-13, 2002 (PubMed).

de Jong, van Puijenbroek, Hendriks et al.: "Microsatellite instability, immunohistochemistry, and additional PMS2 staining in suspected hereditary nonpolyposis colorectal cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 3, pp. 972-80, 2004 (PubMed).

Luo, Lin, Lin: "ATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damage." in: Molecular and cellular biology, Vol. 24, Issue 14, pp. 6430-44, 2004 (PubMed).

Nakagawa, Lockman, Frankel et al.: "Mismatch repair gene PMS2: disease-causing germline mutations are frequent in patients whose tumors stain negative for PMS2 protein, but paralogous genes obscure mutation detection and interpretation." in: Cancer research, Vol. 64, Issue 14, pp. 4721-7, 2004 (PubMed).

Hosts (37), (18)
Reactivities (53), (7), (5), (1), (1)
Applications (36), (29), (12), (9), (7), (2), (2), (1)
Conjugates (2)
Epitopes (8), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
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