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Details for Product No. ABIN405298

Lysine (K)-Specific Demethylase 6B (Kdm6b) (N-Term) antibody

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Antigen
Synonyms JMJD3, 1700064E03Rik, BC038313, Jmjd3, mKIAA0346, jmjd3, kdm6b, si:ch211-237l4.7
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Dog (Canine), Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN405298
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-JMJD3 antibody: synthetic peptide directed towards the N terminal of human JMJD3
Sequence HRAVDPPGARAAREAFALGGLSCAGAWSSCPPHPPPRSAW LPGGRCSASI
Predicted Reactivity Human :100%,   Dog :100%,   Rat :92%,   Mouse :92%,  
Characteristics This is a rabbit polyclonal antibody against JMJD3. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name JMJD3
Background JMJD3 is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. It plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.
Molecular Weight 181kDa
Gene ID 23135
NCBI Accession NP_001073893, NM_001080424
UniProt O15054
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-JMJD3 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Hong, Cho, Yu et al.: "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 47, pp. 18439-44, 2007 (PubMed).

Alternatives for antigen "Lysine (K)-Specific Demethylase 6B (Kdm6b)", type "Antibodies"
Hosts (45)
Reactivities (40), (28), (8), (1), (1)
Applications (43), (14), (7), (4), (4), (1), (1)
Conjugates (2), (2), (2), (1), (1)
Epitopes (16), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
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