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Stratifin antibody (SFN) (Middle Region)

Details for Product anti-SFN Antibody No. ABIN406432, Supplier: Login to see New
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Antigen
Synonyms YWHAS, Er, Mme1, Ywhas
Alternatives
Epitope
Middle Region
(25), (25), (20), (15), (15), (14), (9), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Zebrafish (Danio rerio)
(170), (48), (33), (9), (4), (3), (3), (3), (2), (1), (1)
Host
Rabbit
(132), (31), (17), (3), (1)
Clonality
Polyclonal
Conjugate
This Stratifin antibody is un-conjugated
(9), (8), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(150), (73), (55), (43), (32), (20), (20), (15), (11), (7), (3), (1), (1), (1)
Pubmed 2 references available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human SFN
Blocking Peptide Blocking peptide for this product available: ABIN983633
Sequence FHYEIANSPE EAISLAKTTF DEAMADLHTL SEDSYKDSTL IMQLLRDNLT
Predicted Reactivity Dog : 100 %, Guinea pig : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %
Characteristics This is a rabbit polyclonal antibody against SFN. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name SFN (SFN Antibody Abstract)
Background SFN is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. SFN binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, SFN regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
Molecular Weight 28 kDa
Gene ID 2810
NCBI Accession NM_006142, NP_006133
UniProt P31947
Pathways p53 Signaling
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 248 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Stratifin antibody (SFN) (Middle Region) (ABIN406432) WB Suggested Anti-SFN Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1...
Immunohistochemistry (IHC) image for anti-Stratifin antibody (SFN) (Middle Region) (ABIN406432) anti-Stratifin (SFN) (Middle Region) antibody (Image 2)
Product cited in: Lu, Zhu, Wen et al.: "Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 82, Issue 10, pp. 670-5, 2008 (PubMed).

Background publications Yang, Dicker, Chen et al.: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, 2008 (PubMed).

Catalog No. ABIN406432
$289.00
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