Cholesterol Esterase (Middle Region) antibody

Details for Product No. ABIN487123
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Antigen
Synonyms BAL, BSDL, BSSL, CELL, CEase, FAP, FAPP, LIPA, MODY8, 1810036E18Rik, Bal, Bssl, SC8F4.24
Epitope
Middle Region
(2), (2), (1), (1), (1), (1)
Reactivity
Rat (Rattus), Mouse (Murine), Human
(24), (12), (12), (12), (12), (12), (12), (9), (3)
Host
Rabbit
(31), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (21), (10), (8), (6), (3), (3), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN487123
Quantity 50 µg
Price
289.00 $   Plus shipping costs $45.00
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Immunogen Synthetic peptide directed towards the middle region of human CEL
Sequence VTPTGDSETAPVPPTGDSGAPPVPPTGDSEAAPVPPTDDS KEAQMPAVIR
Predicted Reactivity Human : 100 %, Rat : 100 %, Mouse : 70 %
Characteristics This is a rabbit polyclonal antibody against CEL. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name CEL
Background CEL catalyzes fat and vitamin absorption. CEL acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein.
Molecular Weight 80 kDa
Gene ID 1056
NCBI Accession NM_001807, NP_001798
UniProt P19835
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 756 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
anti-Cholesterol Esterase (Middle Region) antibody WB Suggested Anti-CEL Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: SH-SYSY cell lysate
Product cited in: Panicot-Dubois, Thomas, Furie et al.: "Bile salt-dependent lipase interacts with platelet CXCR4 and modulates thrombus formation in mice and humans." in: The Journal of clinical investigation, Vol. 117, Issue 12, pp. 3708-19, 2007 (PubMed).

Hosts (31), (6)
Reactivities (24), (12), (12), (12), (12), (12), (12), (9), (3)
Applications (24), (21), (10), (8), (6), (3), (3), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2), (2), (1), (1), (1), (1)
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