Eyes Absent Homolog 1 (Drosophila) (EYA1) (Internal Region) antibody

Details for Product No. ABIN487975
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Synonyms EYA1, bop, bor, XEya1, wu:fc13c10, zgc:100770, BOP, BOR, BOS1
Internal Region
(12), (10), (6), (3), (1)
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(27), (26), (15), (1), (1), (1), (1), (1), (1), (1), (1)
(31), (4), (1)
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(27), (10), (10), (4), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN487975
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Immunogen Peptide with sequence C-TDPTAEYSTIHSP, from the internal region of the protein sequence according to NP_742057.1, NP_000494.2, NP_742056.1.
Specificity This antibody reacts to EYA1.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name EYA1
Background EYA1 (Eyes Absent Homolog 1) is a member of the eyes absent (EYA) family of proteins. EYA1 plays a role in transcriptional regulation during organogenesis. It is thought play a role in the development of the kidney, branchial arches, eye and ear. EYA1 is thought to coactivate SIX2, SIX4 and SIX5. EYA1 has intrinsic protein phosphatase activity, and dephosphorylates proteins such as Histone H2.AX phosphorylated on Y142. It is thought to play a role in promoting efficient DNA repair over apoptosis in response to genotypic stress.Synonyms: Eyes absent homolog 1
Gene ID 2138
NCBI Accession NP_000494
UniProt Q99502
Research Area Organogenesis
Application Notes Peptide ELISA: 1/16000. Western blot: Approx 55 kDa band observed in lysates of cell lline HEK293 (calculated MWof 60.5 kDa according to NP_742056.1). Recommended concentration: 1 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
anti-Eyes Absent Homolog 1 (Drosophila) (EYA1) (Internal Region) antibody anti-Eyes Absent Homolog 1 (Drosophila) (EYA1) (Internal Region) antibody
Background publications Orten, Fischer, Sorensen et al.: "Branchio-oto-renal syndrome (BOR): novel mutations in the EYA1 gene, and a review of the mutational genetics of BOR." in: Human mutation, Vol. 29, Issue 4, pp. 537-44, 2008 (PubMed).

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