Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 (SLC2A4) (C-Term) antibody

Details for Product No. ABIN499128
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Antigen
Synonyms GLUT4, SLC2A4, Glut-4, Glut4, glut4, slc2a4
Epitope
C-Term
(19), (9), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(81), (47), (43), (17), (13), (13), (3), (3), (1), (1), (1), (1)
Host
Goat
(62), (28), (4), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(79), (36), (24), (22), (17), (11), (10), (8), (7), (5), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN499128
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Immunogen Peptide with sequence from the C-Terminus of the protein of Human SLC2A4 (NP_001033.1). Genename: SLC2A4
Sequence C-TELEYLGPDE ND
Specificity Recognizes SLC2A4 / GLUT4. Species Reactivity: Tested: Mouse, Rat. Expected from sequence similarity: Human, Cow, Pig.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Alternative Name GLUT4 / SLC2A4
Background The stimulation of glucose uptake by insulin in muscle and adipose tissue requires translocation of the GLUT4 glucose transporter from intracellular storage sites to the cell surface. Activation of phosphatidylinositol-3-OH kinase (PI3K) is required for this trafficking event, but it is not sufficient to produce GLUT4 translocation. Human insulin resistance involves a defect in GLUT4 traffic and targeting leading to accumulation in a dense membrane compartment from which insulin is unable to recruit GLUT4 to the cell surface.
Alternate names: GLUT-4, Glucose transporter 4, Glucose transporter type 4 insulin-responsive, Solute carrier family 2 facilitated glucose transporter member 4
Gene ID 6517
NCBI Accession NP_001033
UniProt P14672
Application Notes Peptide ELISA: Limit Dilution: 1/16000. Western blot: 0.2-0.5 µg/ml. This antibody detects a band of ~45 kDa in Mouse and RatHeart lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hosgood, Menashe, He et al.: "PTEN identified as important risk factor of chronic obstructive pulmonary disease." in: Respiratory medicine, Vol. 103, Issue 12, pp. 1866-70, 2009 (PubMed).

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