BMI1 Polycomb Ring Finger Oncogene (BMI1) (Intermediate Domain) antibody

Details for Product No. ABIN499483
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Antigen
Synonyms FLVI2/BMI1, PCGF4, RNF51, Bmi-1, Pcgf4, AW546694, BMI-1, bmi1, pcgf4, psc1, wu:fb17g03, wu:fd18f06
Epitope
Intermediate Domain
(12), (8), (8), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(116), (59), (43), (20), (19), (18), (6), (6), (5), (3), (2), (1)
Host
Rabbit
(81), (37), (8)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(112), (47), (29), (23), (21), (20), (10), (8), (5), (5), (2), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN499483
Quantity 0.1 mg
Price
401.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Human BMI-1 (Intermediate Domain) Peptide (AP30158CP-N)
Isotype IgG
Specificity BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.
Purification Affinity chromatography purified via peptide column
Alternative Name BMI-1 / RNF51
Background The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c- myc in the generation of mouse lymphomas . BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti- cancer strategies.
Alternate names: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Gene ID 648
NCBI Accession P35226
UniProt P35226
Application Notes ELISA. Western Blot: BMI-1 antibody can be used for detection of BMI-1 at 0.5 to 1 μg/ml. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Alkema, Wiegant, Raap et al.: "Characterization and chromosomal localization of the human proto-oncogene BMI-1." in: Human molecular genetics, Vol. 2, Issue 10, pp. 1597-603, 1994 (PubMed).

Jacobs, Kieboom, Marino et al.: "The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus." in: Nature, Vol. 397, Issue 6715, pp. 164-8, 1999 (PubMed).

Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).

Hosts (81), (37), (8)
Reactivities (116), (59), (43), (20), (19), (18), (6), (6), (5), (3), (2), (1)
Applications (112), (47), (29), (23), (21), (20), (10), (8), (5), (5), (2), (1), (1), (1), (1)
Conjugates (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (8), (8), (6), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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