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BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Intermediate Domain)

Details for Product anti-BMI1 Antibody No. ABIN499483, Supplier: Log in to see
Antigen
  • bmi1
  • pcgf4
  • psc1
  • wu:fb17g03
  • wu:fd18f06
  • FLVI2/BMI1
  • PCGF4
  • RNF51
  • AW546694
  • Bmi-1
  • Pcgf4
  • BMI-1
Alternatives
anti-Human BMI1 antibody for Enzyme Immunoassay
Epitope
Intermediate Domain
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Reactivity
Human, Mouse (Murine), Rat (Rattus)
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This BMI1 antibody is un-conjugated
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Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
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Supplier
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Immunogen Human BMI-1 (Intermediate Domain) Peptide
Isotype IgG
Specificity BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1.
Purification Affinity chromatography purified via peptide column
Alternative Name BMI-1 / RNF51 (BMI1 Antibody Abstract)
Background The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas . BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence (2). Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells (3), suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.Synonyms: BMI1, PCGF4, Polycomb group RING finger protein 4, RING finger protein 51
Gene ID 648
UniProt P35226
Pathways Cell Division Cycle
Application Notes ELISA. Western Blot: BMI-1 antibody can be used for detection of BMI-1 at 0.5 to 1 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Supplier Images
Immunofluorescence (IF) image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Intermediate Domain) (ABIN499483) Immunocytochemistry of BMI-1 in K562 cells with AP30158PU-N BMI-1 antibody at 10 μg/ml.
Western Blotting (WB) image for anti-BMI1 antibody (BMI1 Polycomb Ring Finger Oncogene) (Intermediate Domain) (ABIN499483) Western blot analysis of BMI-1 in K562 cell lysate with AP30158PU-N BMI-1 antibody at...
Background publications Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).

Jacobs, Kieboom, Marino et al.: "The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus." in: Nature, Vol. 397, Issue 6715, pp. 164-8, 1999 (PubMed).

Alkema, Wiegant, Raap et al.: "Characterization and chromosomal localization of the human proto-oncogene BMI-1." in: Human molecular genetics, Vol. 2, Issue 10, pp. 1597-603, 1994 (PubMed).