BR Serine/threonine Kinase 1 (BRSK1) (C-Term) antibody

Details for Product No. ABIN499499
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Synonyms BRSK1, hSAD1, Gm1100, SAD-B, SADB, RGD1563268, Sad-b
(29), (23), (15), (14), (4), (2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(104), (53), (31)
(113), (1)
(7), (7), (7), (6), (6), (6), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(104), (64), (36), (14), (9), (9), (4), (3), (3), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN499499
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Immunogen BRSK1 antibody was raised against a 28 amino acid peptide from near the carboxy terminus of human BRSK1.
Isotype IgG
Specificity This antibody reacts to BRSK1.
Purification Affinity chromatography purified via peptide column
Alternative Name BRSK1
Background BRSK1 was initially identified as a mammalian homolog to the fission yeast S. pombe Cdr2, a mitosis-regulatory kinase and also shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK1 is unbiquitously expressed, with highest levels of expression in the brain and testes. Similar to its yeast homolog, BRSK1 is thought to be involved in stress-induced cell cycle arrest. Overexpression of this protein leads to the G2/M arrest in HeLa S2 cells and UV-induced G2/M arrest could be partially abrogated by reduced expression of BRSK1 through the use of siRNA, indicating its role in DNA damage checkpoint function. More recently, it has been shown that both BRSK1 and the related protein BRSK2 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. At least two isoforms of BRSK1 are known to exist.Synonyms: BR serine/threonine-protein kinase 1, KIAA1811, SAD-B, SAD1, SAD1 kinase, Serine/threonine kinase SAD-B
Gene ID 84446
UniProt Q8TDC3
Research Area Kinases/Phosphatases
Application Notes ELISA. Western Blot: BRSK1 antibody can be used for detection of BRSK1 at 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Kishi, Pan, Crump et al.: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, 2005 (PubMed).

Lu, Niida, Nakanishi: "Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31164-70, 2004 (PubMed).

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