BRSK1 antibody (AA 310-510)

Catalog No. ABIN7265908

This Rabbit Polyclonal antibody specifically detects BRSK1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for BRSK1 antibody (AA 310-510) (ABIN7265908)

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRSK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-BRSK1 Antibody

Binding Specificity: AA 310-510

Purpose: BRSK1 Rabbit pAb

Sequence: PSNGELDPDV LESMASLGCF RDRERLHREL RSEEENQEKM IYYLLLDRKE RYPSCEDQDL PPRNDVDPPR KRVDSPMLSR HGKRRPERKS MEVLSITDAG GGGSPVPTRR ALEMAQHSQR SRSVSGASTG LSSSPLSSPR SPVFSFSPEP GAGDEARGGG SPTSKTQTLP SRGPRGGGAG EQPPPPSARS TPLPGPPGSP R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 310-510 of human BRSK1 (NP_115806.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for BRSK1

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Alternative Name: BRSK1

Background: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2 at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.,BRSK1,hSAD1,Signal Transduction,Kinase,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,BRSK1

Molecular Weight: 38kDa/85kDa/86kDa

Gene ID: 84446

UniProt: Q8TDC3