Dapper, Antagonist of beta-Catenin, Homolog 2 (Xenopus Laevis) (DACT2) (N-Term) antibody

Details for Product No. ABIN499702
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Synonyms 2900084M21Rik, A630024E20, Dpr2, Frd2, dapper2, C6orf116, DAPPER2, DPR2, RP11-503C24.7, bA503C24.7
Human, Mouse (Murine), Rat (Rattus)
(23), (19), (19)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(14), (10), (10), (8), (6), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499702
401.50 $
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Immunogen Dact2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
Isotype IgG
Specificity This antibody reacts to DACT2.
Purification Affinity chromatography purified via peptide column
Alternative Name DACT2
Background The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a b-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-b receptors. At least two isoforms of Dact2 are known to exist.Synonyms: C6orf116, DAPPER2, DPR2, PP13671, dapper homolog 2
Gene ID 168002
NCBI Accession NP_999627
UniProt Q5SW24
Application Notes ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Waxman, Hocking, Stoick et al.: "Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes." in: Development (Cambridge, England), Vol. 131, Issue 23, pp. 5909-21, 2004 (PubMed).

Shimogori, VanSant, Paik et al.: "Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex." in: The Journal of comparative neurology, Vol. 473, Issue 4, pp. 496-510, 2004 (PubMed).

Katoh, Katoh: "Identification and characterization of human DAPPER1 and DAPPER2 genes in silico." in: International journal of oncology, Vol. 22, Issue 4, pp. 907-13, 2003 (PubMed).

Cheyette, Waxman, Miller et al.: "Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation." in: Developmental cell, Vol. 2, Issue 4, pp. 449-61, 2002 (PubMed).

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