Tumor Necrosis Factor Receptor Superfamily, Member 10c, Decoy Without An Intracellular Domain (TNFRSF10C) antibody

Details for Product No. ABIN499722
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Antigen
Synonyms CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID, TNFRSF10C
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(94), (6), (6), (4)
Host
Rabbit
(55), (41), (3), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(15), (10), (3), (1), (1), (1)
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(53), (50), (18), (9), (9), (8), (7), (2), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
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Catalog No. ABIN499722
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Immunogen Human DcR1 Peptide
Isotype IgG
Specificity DcR1 antibody was raised against a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.
Purification Affinity chromatography purified via peptide column
Alternative Name CD263 / TRAILR3
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL (1-3). Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT (2-7) and DcR2/TRAIL-R4/TRUNDD (8-10). DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Alternate names: Antagonist decoy receptor for TRAIL/Apo-2L, DCR1, Decoy TRAIL receptor without death domain, Decoy receptor 1, LIT, Lymphocyte inhibitor of TRAIL, TNF-related apoptosis- inducing ligand receptor 3, TNFRSF10C, TRAIL receptor 3, TRAIL-R3, TRID, Trail receptor without an intracellular domain, Tumor necrosis factor receptor superfamily member 10C
Gene ID 8794
UniProt O14798
Research Area Signaling, Apoptosis/Necrosis
Application Notes ELISA. Western Blot: 0.5 to 1 μg/ml. An approximate 65 kDa band can be detected. Immunofluorescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Pan, ORourke, Chinnaiyan et al.: "The receptor for the cytotoxic ligand TRAIL." in: Science (New York, N.Y.), Vol. 276, Issue 5309, pp. 111-3, 1997 (PubMed).

Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).

Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).

Degli-Esposti, Smolak, Walczak et al.: "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1165-70, 1997 (PubMed).

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