DcR1 antibody

Catalog No. ABIN301991

The Mouse Monoclonal anti-DcR1 antibody is suitable to detect DcR1 in samples from Human. It has been validated for FACS.

Quick Overview for DcR1 antibody (ABIN301991)

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DcR1 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: TRAIL-R3-02

Product Details anti-DcR1 Antibody

Purpose: Anti-Hu CD263 Purified Azide Free

Cross-Reactivity (Details): Human

Characteristics: The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: TRAIL-R3-hIgGhc fusion protein

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Preservative: Azide free

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for DcR1

Target: DcR1 (TNFRSF10C) (Tumor Necrosis Factor Receptor Superfamily, Member 10c (TNFRSF10C))

Alternative Name: CD263

Background: TNF receptor superfamily member 10c,TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).,TNFRSF10C, DcR1, TRAIL-R3, TRID, LIT

Gene ID: 8794

UniProt: O14798

Pathways: Apoptosis