Death Effector Domain Containing 2 (DEDD2) antibody

Details for Product No. ABIN499734
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Synonyms FLAME-3, 2410050E11Rik, MGC145883, DEDD2, DEDD, DKFZp459K109
Human, Mouse (Murine), Rat (Rattus)
(38), (22), (22), (12), (11), (11)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(30), (15), (9), (5), (3), (3), (1), (1)
Pubmed 3 references available
Catalog no. ABIN499734
Quantity 0.1 mg
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Immunogen Human DEDD2 Peptide (AP30285CP-N)
Isotype IgG
Specificity DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near the amino-terminus of human DEDD2.
Purification Immunoaffinity chromatography purified IgG
Alternative Name DEDD2
Background Apoptotic signals are often triggered by cell surface death receptors through protein- protein interactions mediated by conserved domains such as the death effector domain (1). A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified and its over-expression in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor- induced apoptosis (3). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Alternate names: DED-containing protein FLAME-3, DEDD-2, DNA-binding death effector domain-containing protein 2, FADD-like anti-apoptotic molecule 3, FLAME-3, FLAME3, PSEC0004
Gene ID 162989
NCBI Accession NP_579874
UniProt Q8WXF8
Research Area Apoptosis/Necrosis, Death Receptors
Application Notes ELISA. Western Blot: 0.5 to 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Roth, Stenner-Liewen, Pawlowski et al.: "Identification and characterization of DEDD2, a death effector domain-containing protein." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7501-8, 2002 (PubMed).

Alcivar, Hu, Tang et al.: "DEDD and DEDD2 associate with caspase-8/10 and signal cell death." in: Oncogene, Vol. 22, Issue 2, pp. 291-7, 2003 (PubMed).

Tibbetts, Zheng, Lenardo: "The death effector domain protein family: regulators of cellular homeostasis." in: Nature immunology, Vol. 4, Issue 5, pp. 404-9, 2003 (PubMed).

Hosts (43)
Reactivities (38), (22), (22), (12), (11), (11)
Applications (30), (15), (9), (5), (3), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (3), (1), (1), (1), (1)
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