Death Effector Domain Containing 2 (DEDD2) antibody

Antigen: Death Effector Domain Containing 2 (DEDD2)

Synonyms: FLAME-3, DEDD2, MGC140424, MGC145883, DEFT, KE05, DEDD1, FLDED1, CASP8IP1, 2410050E11Rik, DEDD, MGC127710, DKFZp459K109

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Enzyme Immunoassay (EIA), Western Blotting (WB)

Catalog no.: ABIN499734

Additional Information

Characteristics: Synonyms: FLAME3, FLAME-3, PSEC0004, FADD-like anti-apoptotic molecule 3, DEDD-2, DNA-bindingdeath effector domain-containing protein 2, DED-containing protein FLAME-3

Alternative name: DEDD2

Gene ID: 162989

Swiss-Prot: Q8WXF8

Immunogen: Human DEDD2 Peptide (ABIN499733)

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Isotype: IgG  (Matching secondary antibodies)

Description: Apoptotic signals are often triggered by cell surface death receptors throughprotein-protein interactions mediated by conserved domains such as the death effectordomain (1). A novel death effector domain (DED)-containing protein, DEDD2, has beenrecently identified and its over-expression in transfected cells induces moderate apoptosisand results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD (2). More recently, work has shown that DEDD2 can bind caspase-8 and -10 in addition to FLIPbut not FADD (2,3). Like the related protein DEDD, DEDD2 translocates from the cytosol tothe nucleus upon induction of apoptosis, and it has been suggested that DEDD2 maytarget caspase-8 to the nucleus and that DEDD2 thus plays a critical role in deathreceptor-induced apoptosis (3). At least two alternatively spliced transcript variantsencoding distinct isoforms have been found for DEDD2.

Specificity: DEDD2 antibody was raised against a peptide corresponding to 11 amino acids near theamino-terminus of human DEDD2. Species: Human, Mouse, Rat. Others not tested. Add. Information: Blocking peptide available: blocking peptide (ABIN499733)

Application Details

Application Notes: ELISA. Western Blot: 0.5 to 1 μg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.

Purification: Aff - Purified

Buffer: PBS containing 0.02% sodium azide.

Storage: Store the antibody undiluted at 2-8°C. Shelf life: one year from despatch.

Research Area: Apoptosis/Necrosis, Death Receptors

Restrictions: For Research Use only