Transmembrane Protein 173 (TMEM173) (C-Term) antibody

Details for Product No. ABIN500288
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Antigen
Synonyms ERIS, MITA, MPYS, NET23, STING, 2610307O08Rik, Mita, RGD1562552
Epitope
C-Term
(24), (16), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(71), (24), (15), (12), (12), (12)
Host
Rabbit
(53), (20)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
(50), (37), (21), (14), (12), (11), (10), (4), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN500288
401.50 $
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Immunogen TMEM173 antibody was raised against a 17 amino acid peptide near the carboxy terminus of Human TMEM173.
Isotype IgG
Specificity This antibody detects TMEM173 / STING.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse.
Purification Peptide Affinity Chromatography
Alternative Name TMEM173 / STING
Background MPYS (TMEM173 / STING) is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.Synonyms: MITA, Mediator of IRF3 activation, Stimulator of interferon genes protein, Transmembrane protein 173
Gene ID 340061
NCBI Accession NP_938023
UniProt Q86WV6
Application Notes ELISA. Western blot: (1-2 μg/mL). A-20 cell tissue lysate can be used as positive control. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Jin, Waterman, Jonscher et al.: "MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals." in: Molecular and cellular biology, Vol. 28, Issue 16, pp. 5014-26, 2008 (PubMed).

Zhong, Yang, Li et al.: "The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation." in: Immunity, Vol. 29, Issue 4, pp. 538-50, 2008 (PubMed).

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