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Reticulon 4 (RTN4) (Isoform 1) antibody

Details for Product No. ABIN500369
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Antigen
Synonyms
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, ... show more
RTN4-Cw, DKFZp459C0314, NOGO, NOGO-A, reticulon-4, ASY, NI220/250, NOGOC, NSP, NSP-CL, Nbla00271, Nbla10545, Nogo-B, Nogo-C, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, 1110020G17Rik, AA407876, AA409940, AA960376, C130026I10Rik, NgA, Nogo-A, mKIAA0886, mKIAA4153, NI-250, Nogo, Vp20, r, rat N, rat NogoA, NGR, NOGOR, NgR, NgR1, Nogor show less
Epitope
Isoform 1
(17), (15), (12), (6), (5), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(89), (73), (72), (3), (2), (2), (1)
Host
Rabbit
(99), (7), (4), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(88), (49), (35), (27), (20), (6), (5), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN500369
401.50 $
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Immunogen NogoA antibody was raised against a 19 amino acid peptide from near the center of human NogoA.
Isotype IgG
Specificity This antibody detects RTN4 / NOGO at Center. It is specific for NogoA and NogoE. Species Reactivity: Tested: Human, mouse, rat
Purification Peptide affinity chromatography
Alternative Name Reticulon-4 / RTN4
Background NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin- associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients. Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. At least five isoforms of Nogo are known to exist.
Alternate names: Foocen, KIAA0886, NOGO, NSP, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, Reticulon-5
Gene ID 57142
NCBI Accession NP_065393
UniProt Q9NQC3
Application Notes ELISA. Western blot: 0.5 – 1 μg/ml. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Expiry Date 12 months
Background publications Chen, Huber, van der Haar et al.: "Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1." in: Nature, Vol. 403, Issue 6768, pp. 434-9, 2000 (PubMed).

Dupuis, Gonzalez de Aguilar, di Scala et al.: "Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis." in: Neurobiology of disease, Vol. 10, Issue 3, pp. 358-65, 2002 (PubMed).

Yan, Shi, Hu et al.: "Reticulon proteins: emerging players in neurodegenerative diseases." in: Cellular and molecular life sciences : CMLS, Vol. 63, Issue 7-8, pp. 877-89, 2006 (PubMed).

Schweigreiter, Bandtlow: "Nogo in the injured spinal cord." in: Journal of neurotrauma, Vol. 23, Issue 3-4, pp. 384-96, 2006 (PubMed).

Validation Images
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