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CD13 antibody (Alanyl (Membrane) Aminopeptidase) (APC)

Details for Product anti-ANPEP Antibody No. ABIN501185, Supplier: Login to see New
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Synonyms Apn, pepN, SC8E4A.13, APN, CD13, GP150, LAP1, P150, PEPN, AP-M, AP-N, Cd13, Apm, KZP, Lap1, rAPN, APDE, p150
Human, Primate
(322), (97), (15), (12), (8), (8), (8), (4), (3)
(278), (77), (63), (2), (2)
Clonality (Clone)
Monoclonal ()
This CD13 antibody is conjugated to APC
(67), (54), (30), (18), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Flow Cytometry (FACS)
(289), (111), (67), (67), (56), (52), (37), (31), (23), (9), (9), (5), (3), (1), (1)
Pubmed 6 references available
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Quantity 100 tests
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Human AML cells
Clone WM15
Isotype IgG1
Specificity This antibody recognises the human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Cross-Reactivity (Details) Species reactivity (tested):Human, primates
Purification Size-exclusion chromatography
Alternative Name CD13 (ANPEP Antibody Abstract)
Background CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.Synonyms: ANPEP, APN, Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, PEPN, gp150
Gene ID 290
NCBI Accession NP_001141
UniProt P15144
Research Area Stem Cells, Hematopoietic Progenitors, CD Antigens, Surface Receptors of Immune Cells, Extracellular Matrix, Signaling
Application Notes Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole bloodor 10^6 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2 % (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Dilute only prior to immediate use
Storage 4 °C
Storage Comment Store the antibody (undiluted) at 2-8 °C. DO NOT FREEZE! Freezing alkaline phosphatase conjugates will result in a substantial loss of enzymatic activity.
Background publications Terauchi, Kajiyama, Shibata et al.: "Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells." in: BMC cancer, Vol. 7, pp. 140, 2007 (PubMed).

Petrovic, Schacke, Gahagan et al.: "CD13/APN regulates endothelial invasion and filopodia formation." in: Blood, Vol. 110, Issue 1, pp. 142-50, 2007 (PubMed).

Tokuhara, Hattori, Ishida et al.: "Clinical significance of aminopeptidase N in non-small cell lung cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 13, pp. 3971-8, 2006 (PubMed).

Favaloro, Browning, Facey: "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated." in: Experimental hematology, Vol. 21, Issue 13, pp. 1695-701, 1993 (PubMed).

Bradstock, Favaloro, Kabral et al.: "Myeloid progenitor surface antigen identified by monoclonal antibody." in: British journal of haematology, Vol. 61, Issue 1, pp. 11-20, 1985 (PubMed).

Bradstock, Favaloro, Kabral et al.: "Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells." in: Pathology, Vol. 17, Issue 3, pp. 392-9, 1986 (PubMed).

Catalog No. ABIN501185
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