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Calcium Channel, Voltage-Dependent, beta 2 Subunit (CACNB2) (Middle Region) antibody

Details for Product No. ABIN501436

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Antigen
Synonyms	Cacnb2, CACNB2, CACNLB2, CAVB2, MYSB, CAB2, AW060387, Cavbeta2, Cchb2, Cacnlb2
Epitope	Alternatives Middle Region (20), (18), (15), (15), (8), (8), (7), (3), (2), (1)
Reactivity	Alternatives Rabbit, Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine), Xenopus laevis, Human (93), (52), (33), (20), (14), (8), (7), (2), (1)
Host	Alternatives Rabbit (77), (33), (4)
Clonality	Polyclonal
Conjugate	Alternatives Un-conjugated (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application	Alternatives Western Blotting (WB) (100), (23), (20), (17), (17), (10), (4), (2), (2), (1)
	1 reference available
Quantity	50 μg
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Shipping to	United States (Change)
Availability	Will be delivered in 2 to 3 Business Days

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Catalog No. ABIN501436

289.00 $
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Immunogen	Synthetic peptide directed towards the middle region of human CACNB2
Sequence	DACEHLADYL EAYWKATHPP SSSLPNPLLS RTLATSSLPL SPTLASNSQG
Predicted Reactivity	Bovine : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Dog : 90 %, Guinea pig : 90 %, Rat : 90 %
Characteristics	This is a rabbit polyclonal antibody against CACNB2. It was validated on Western Blot using a cell lysate as a positive control.
Purification	Affinity Purified

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Alternative Name	CACNB2
Background	CACNB2 belongs to the calcium channel beta subunit family.The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.Defects in CACNB2 are the cause of Brugada syndrome type 4 (BRS4).
Molecular Weight	68 kDa
Gene ID	783
NCBI Accession	NM_201572, NP_963866
UniProt	A6PVM7
Research Area	Neurology

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Application Notes	Optimal working dilutions should be determined experimentally by the investigator.
Comment	Antigen size: 608 AA
Restrictions	For Research Use only

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Format	Lyophilized
Reconstitution	Add 50 µL of distilled water.
Concentration	1 mg/mL
Buffer	PBS buffer with 2 % sucrose
Handling Advice	Avoid repeated freeze-thaw cycles.
Storage	-20 °C
Storage Comment	For longer periods of storage, store at -20 °C

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Supplier Images	WB Suggested Anti-CACNB2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: MCF7 cell lysate

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Background publications	Uhl, Liu, Drgon et al.: "Molecular genetics of successful smoking cessation: convergent genome-wide association study results." in: Archives of general psychiatry, Vol. 65, Issue 6, pp. 683-93, 2008 (PubMed).

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