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Details for Product No. ABIN502677

Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody

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Synonyms OPLL, Col6a-1, AI747156, RGD1565398, COL6A1
»Alternatives Middle Region
»Alternatives Mouse (Murine), Rat (Rattus), Pig (Porcine), Cow (Bovine), Human, Chicken
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN502677
Quantity 50 µg
289.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen The immunogen for anti-COL6A1 antibody: synthetic peptide directed towards the middle region of human COL6A1
Predicted Reactivity Dog : 100%, Human : 100%, Pig : 100%, Rabbit : 100%, Bovine : 92%, Horse : 92%, Mouse : 85%, Rat : 85%
Characteristics This is a rabbit polyclonal antibody against COL6A1. It was validated on Western Blot using a cell lysate as a positive control. We strive to provide antibodies covering each member of a whole protein family of your interest.
Purification Affinity Purified
Alternative Name COL6A1
Background COL6A1 is a collagen VI which acts as a cell-binding protein.Defects in COL6A1 are a cause of Bethlem myopathy (BM).The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
Molecular Weight 106kDa
Gene ID 1291
NCBI Accession NP_001839, NM_001848
UniProt P12109
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water
Concentration 1mg/mL
Buffer Final anti-COL6A1 antibody concentration is 1 mg/mL in PBS buffer.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Background publications Hicks, Lampe, Barresi et al.: "A refined diagnostic algorithm for Bethlem myopathy." in: Neurology, Vol. 70, Issue 14, pp. 1192-9, 2008 (PubMed).

Alternatives for antigen "Collagen, Type VI, alpha 1 (COL6A1)", type "Antibodies"
Hosts (20)
Reactivities (15), (7), (2)
Applications (18), (12), (11), (8), (6), (4), (4), (3)
Conjugates (4)
Epitopes (3), (3), (3), (2), (2)