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Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody

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Synonyms COL6A1, OPLL, AI747156, Col6a-1, RGD1565398
Middle Region
(8), (6), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1)
Chicken, Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(42), (19), (5), (2)
Western Blotting (WB)
(38), (32), (21), (19), (12), (10), (10), (9), (5), (1)
Pubmed 1 reference available
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Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the middle region of human COL6A1
Blocking Peptide Blocking peptide for this product available: ABIN975168
Predicted Reactivity Dog : 100 %, Human : 100 %, Pig : 100 %, Rabbit : 100 %, Bovine : 90 %, Horse : 90 %, Mouse : 80 %, Rat : 80 %
Characteristics This is a rabbit polyclonal antibody against COL6A1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name COL6A1 (COL6A1 Antibody Abstract)
Background COL6A1 is a collagen VI which acts as a cell-binding protein.Defects in COL6A1 are a cause of Bethlem myopathy (BM).The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy.
Molecular Weight 106 kDa
Gene ID 1291
NCBI Accession NP_001839, NM_001848
UniProt P12109
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 1028 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody (ABIN502677) WB Suggested Anti-COL6A1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Image no. 2 for anti-Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody (ABIN502677) anti-Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody (Image 2)
Western Blotting (WB) image for anti-Collagen, Type VI, alpha 1 (COL6A1) (Middle Region) antibody (ABIN502677) WB Suggested Anti-COL6A1
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500 ...
Background publications Hicks, Lampe, Barresi et al.: "A refined diagnostic algorithm for Bethlem myopathy." in: Neurology, Vol. 70, Issue 14, pp. 1192-9, 2008 (PubMed).

Catalog No. ABIN502677
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