beta 1,3-Galactosyltransferase-Like (B3GALTL) (Middle Region) antibody

Details for Product No. ABIN503023
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Synonyms B3GLCT, B3GTL, B3Glc-T, Gal-T, beta3Glc-T, Gm1057
Middle Region
(2), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(15), (3)
(14), (1)
Western Blotting (WB)
(15), (11), (10), (2)
Pubmed 1 reference available
Quantity 50 μg
Shipping to United States ( )
Availability Will be delivered in 2 to 3 Business Days
Immunogen Synthetic peptide directed towards the middle region of human B3GALTL
Predicted Reactivity Dog : 92 %
Characteristics This is a rabbit polyclonal antibody against B3GALTL. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name B3GALTL (B3GALTL Antibody Abstract)
Background B3GALTL is the O-fucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. B3GALTL specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.B3GALTL is a beta-1,3-glucosyltransferase involved in the synthesis of the unusual O-linked disaccharide glucosyl-beta-1,3-fucose-O- found on the thrombospondin (see THBS1, MIM 188060) type-1 repeats (TSRs) of many biologically important proteins. Biosynthesis of glucosyl-beta-1,3-fucose-O- is initiated by protein O-fucosyltransferase-2 (POFUT2, MIM 610249), which attaches the fucosyl residue to a serine or threonine within the TSR. B3GALTL subsequently transfers the glucose onto TSR-fucose (Hess et al., 2008 [PubMed 18199743]).
Molecular Weight 56 kDa
Gene ID 145173
NCBI Accession NM_194318, NP_919299
UniProt Q6Y288
Application Notes Optimal working dilutions should be determined experimentally by the investigator.

Antigen size: 498 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-beta 1,3-Galactosyltransferase-Like (B3GALTL) (Middle Region) antibody (ABIN503023) WB Suggested Anti-B3GALTL Antibody Titration: 0.2-1 ug/ml
ELISA Titer: <...
Background publications Hess, Keusch, Oberstein et al.: "Peters Plus syndrome is a new congenital disorder of glycosylation and involves defective Omicron-glycosylation of thrombospondin type 1 repeats." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7354-60, 2008 (PubMed).

Catalog No. ABIN503023
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