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URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibody

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Antigen
Synonyms c19orf2, C19orf2, NNX3, PPP1R19, RMP, URI
Epitope
Middle Region
(18), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(31), (3), (3), (1), (1)
Host
Rabbit
(26), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(23), (11), (5), (4), (4), (3)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human C19orf2
Blocking Peptide Blocking peptide for this product available: ABIN974085
Sequence NGEYVPRKSI LKSRSRENSV CSDTSESSAA EFDDRRGVLR SISCEEATCS
Predicted Reactivity Rabbit : 100 %, Horse : 80 %
Characteristics This is a rabbit polyclonal antibody against C19orf2. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name C19orf2 (URI1 Antibody Abstract)
Background The function of the C19orf2 protein remains unknown.The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Molecular Weight 55 kDa
Gene ID 8725
NCBI Accession NP_604431, NM_134447
UniProt Q6NX55
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 495 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibody (ABIN503187) WB Suggested Anti-C19orf2 Antibody Titration: 0.2-1 ug/ml
Positive Contr...
Western Blotting (WB) image for anti-URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibody (ABIN503187) Host: Rabbit
Target Name: URI1
Sample Tissue: Human Fetal Lung
A...
Western Blotting (WB) image for anti-URI1, Prefoldin-Like Chaperone (URI1) (Middle Region) antibody (ABIN503187) Host: Rabbit
Target Name: URI1
Sample Tissue: HepG2
Antibody Dil...
Background publications Djouder, Metzler, Schmidt et al.: "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling." in: Molecular cell, Vol. 28, Issue 1, pp. 28-40, 2007 (PubMed).

Catalog No. ABIN503187
$289.00
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