URI1 antibody (Middle Region)

Catalog No. ABIN2784320

The Rabbit Polyclonal anti-URI1 antibody (ABIN2784320) specifically detects URI1 in WB. The antibody is reactive with Human, Mouse, Rat, Dog, Cow, Horse, Rabbit and Guinea Pig samples.

Quick Overview for URI1 antibody (Middle Region) (ABIN2784320)

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This URI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-URI1 Antibody

Binding Specificity: Middle Region

Purpose: C19orf2 Antibody - middle region

Sequence: NGEYVPRKSI LKSRSRENSV CSDTSESSAA EFDDRRGVLR SISCEEATCS

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 100%, Rat: 80%

Characteristics: This is a rabbit polyclonal antibody against C19orf2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human C19orf2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP50771-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for URI1

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Alternative Name: C19orf2

Background:

Background Information: The function of the C19orf2 protein remains unknown.The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene Name: URI1, prefoldin-like chaperone

Alternative Symbols: RMP, URI, NNX3, C19orf2, PPP1R19

Protein Name: Chromosome 19 open reading frame 2 EMBL AAH67259.1

Molecular Weight: 55kDa

Gene ID: 8725

NCBI Accession: NP_604431

UniProt: Q6NX55