Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody

Details for Product No. ABIN560675
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Antigen
Synonyms DYRK1A, dyrk, dyrk1, hp86, mnb, mnbh, DYRK, DYRK1, HP86, MNB, MNBH, MRD7, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47
Epitope
AA 674-763
(33), (24), (14), (14), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(104), (30), (28)
Host
Mouse
(96), (8), (4), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (8), (8), (7), (7), (7), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(102), (56), (11), (10), (9), (7), (6), (5), (4), (1), (1), (1)
Pubmed 21 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 11 to 12 Business Days
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Catalog No. ABIN560675
330.00 $
Plus shipping costs $45.00 and $22.00 dry ice

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Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: NQGNQAYQNRPVAANTLDFG QNGAMDVNLTVYSNPRQETG IAGHPTYQFSANTGPAHYMT EGHLTMRQGADREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Characteristics Mouse monoclonal antibody raised against a partial recombinant DYRK1A.
Alternative Name DYRK1A
Background Gene: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK, DYRK1, HP86, MNB, MNBH
Gene ID 1859
NCBI Accession NM_001396, NP_001387
Research Area Neurology, Neurogenesis
Application Notes Application specialization: Cell lysate, Recombinant protein
Restrictions For Research Use only
Buffer 1x PBS, pH 7.2
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in Hela S3 NE.
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (2) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in 293
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (3) Detection limit for recombinant GST tagged DYRK1A is approximately 0.03 ng/mL as a capture antibody.
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (4) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in NIH/3T3
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (5) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in PC-12
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (6) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in Raw 264.7
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (7) Western Blot detection against Immunogen (35.53 kDa) .
Product cited in: Rachdi, Kariyawasam, Guez et al.: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, 2014 (PubMed).

Hibaoui, Grad, Letourneau et al.: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, 2014 (PubMed).

Fant, Durieu, Chicanne et al.: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, 2014 (PubMed).

Pons-Espinal, Martinez de Lagran, Dierssen: "Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A." in: Neurobiology of disease, Vol. 60, pp. 18-31, 2013 (PubMed).

Stefos, Soppa, Dierssen et al.: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, 2013 (PubMed).

Laguna, Barallobre, Marchena et al.: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, 2013 (PubMed).

Tlili, Jacobs, de Koning et al.: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, 2013 (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, 2013 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Guo, Kesimer, Tolun et al.: "The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status." in: Scientific reports, Vol. 2, pp. 640, 2012 (PubMed).

Abekhoukh, Planque, Ripoll et al.: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." in: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, 2013 (PubMed).

Planque, Dairou, Noll et al.: "Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain." in: Journal of molecular neuroscience : MN, 2012 (PubMed).

Malinge, Bliss-Moreau, Kirsammer et al.: "Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 948-62, 2012 (PubMed).

Guedj, Pereira, Najas et al.: "DYRK1A: a master regulatory protein controlling brain growth." in: Neurobiology of disease, Vol. 46, Issue 1, pp. 190-203, 2012 (PubMed).

Park, Sung, Park et al.: "Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP." in: Journal of cell science, Vol. 125, Issue Pt 1, pp. 67-80, 2012 (PubMed).

Ahmed, Sturgeon, Ellison et al.: "Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome." in: Journal of proteome research, Vol. 11, Issue 2, pp. 1251-63, 2012 (PubMed).

Sheppard, Plattner, Rubin et al.: "Altered regulation of tau phosphorylation in a mouse model of down syndrome aging." in: Neurobiology of aging, Vol. 33, Issue 4, pp. 828.e31-44, 2012 (PubMed).

Toiber, Azkona, Ben-Ari et al.: "Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations." in: Neurobiology of disease, Vol. 40, Issue 1, pp. 348-59, 2010 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Raaf, Noll, Cherifi et al.: "Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats." in: International journal of cardiology, Vol. 145, Issue 2, pp. 306-7, 2010 (PubMed).

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