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Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody

Details for Product No. ABIN560675
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Antigen
Synonyms MNB, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47, DYRK, DYRK1, HP86, MNBH, MRD7, mnb, DYRK1A, dyrk, dyrk1, hp86, mnbh
Epitope
AA 674-763
(16), (15), (7), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(70), (29), (27), (12), (12), (12), (12)
Host
Mouse
(73), (3), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), ELISA
(70), (46), (11), (10), (8), (5), (5), (5), (4)
Pubmed 28 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 11 to 12 Business Days
Catalog No. ABIN560675
394.24 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: NQGNQAYQNRPVAANTLDFG QNGAMDVNLTVYSNPRQETG IAGHPTYQFSANTGPAHYMT EGHLTMRQGADREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Characteristics Mouse monoclonal antibody raised against a partial recombinant DYRK1A.
Alternative Name DYRK1A
Background Gene: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK, DYRK1, HP86, MNB, MNBH
Gene ID 1859
NCBI Accession NM_001396, NP_001387
Research Area Neurology, Neurogenesis
Application Notes Application specialization: Cell lysate, Recombinant protein
Restrictions For Research Use only
Buffer 1x PBS, pH 7.2
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Supplier Images
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in Hela S3 NE.
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (2) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in 293
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (3) Detection limit for recombinant GST tagged DYRK1A is approximately 0.03 ng/mL as a capture antibody.
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (4) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in NIH/3T3
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (5) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in PC-12
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (6) DYRK1A monoclonal antibody (M01), clone 7D10. Western Blot analysis of DYRK1A expression in Raw 264.7
anti-Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody (7) Western Blot detection against Immunogen (35.53 kDa) .
Product cited in: Aranda, Alvarez, Turró et al.: "Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 5899-911, 2008 (PubMed).

Hamelet, Noll, Ripoll et al.: "Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice." in: Biochemical and biophysical research communications, Vol. 378, Issue 3, pp. 673-7, 2008 (PubMed).

Guedj, Sébrié, Rivals et al.: "Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A." in: PLoS ONE, Vol. 4, Issue 2, pp. e4606, 2009 (PubMed).

Scales, Lin, Kraus et al.: "Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2424-35, 2009 (PubMed).

Lee, Ha, Kim et al.: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, 2009 (PubMed).

Noll, Planque, Ripoll et al.: "DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase." in: PLoS ONE, Vol. 4, Issue 10, pp. e7540, 2009 (PubMed).

Raaf, Noll, Cherifi et al.: "Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats." in: International journal of cardiology, Vol. 145, Issue 2, pp. 306-7, 2010 (PubMed).

Guo, Williams, Schug et al.: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Toiber, Azkona, Ben-Ari et al.: "Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations." in: Neurobiology of disease, Vol. 40, Issue 1, pp. 348-59, 2010 (PubMed).

Sheppard, Plattner, Rubin et al.: "Altered regulation of tau phosphorylation in a mouse model of down syndrome aging." in: Neurobiology of aging, Vol. 33, Issue 4, pp. 828.e31-44, 2012 (PubMed).

Ahmed, Sturgeon, Ellison et al.: "Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome." in: Journal of proteome research, Vol. 11, Issue 2, pp. 1251-63, 2012 (PubMed).

Park, Sung, Park et al.: "Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP." in: Journal of cell science, Vol. 125, Issue Pt 1, pp. 67-80, 2012 (PubMed).

Guedj, Pereira, Najas et al.: "DYRK1A: a master regulatory protein controlling brain growth." in: Neurobiology of disease, Vol. 46, Issue 1, pp. 190-203, 2012 (PubMed).

Malinge, Bliss-Moreau, Kirsammer et al.: "Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 948-62, 2012 (PubMed).

Planque, Dairou, Noll et al.: "Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain." in: Journal of molecular neuroscience : MN, 2012 (PubMed).

Abekhoukh, Planque, Ripoll et al.: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." in: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, 2013 (PubMed).

Guo, Kesimer, Tolun et al.: "The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status." in: Scientific reports, Vol. 2, pp. 640, 2012 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Arque, Casanovas, Dierssen: "Dyrk1A is dynamically expressed on subsets of motor neurons and in the neuromuscular junction: possible role in Down syndrome." in: PLoS ONE, Vol. 8, Issue 1, pp. e54285, 2013 (PubMed).

Tlili, Jacobs, de Koning et al.: "Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice." in: Biochimica et biophysica acta, Vol. 1832, Issue 6, pp. 718-28, 2013 (PubMed).

Laguna, Barallobre, Marchena et al.: "Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome." in: Human molecular genetics, Vol. 22, Issue 14, pp. 2775-84, 2013 (PubMed).

Stefos, Soppa, Dierssen et al.: "NGF upregulates the plasminogen activation inhibitor-1 in neurons via the calcineurin/NFAT pathway and the Down syndrome-related proteins DYRK1A and RCAN1 attenuate this effect." in: PLoS ONE, Vol. 8, Issue 6, pp. e67470, 2013 (PubMed).

Pons-Espinal, Martinez de Lagran, Dierssen: "Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A." in: Neurobiology of disease, Vol. 60, pp. 18-31, 2013 (PubMed).

Fant, Durieu, Chicanne et al.: "cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease." in: Molecular pharmacology, Vol. 85, Issue 3, pp. 441-50, 2014 (PubMed).

Hibaoui, Grad, Letourneau et al.: "Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21." in: EMBO molecular medicine, Vol. 6, Issue 2, pp. 259-77, 2014 (PubMed).

Rachdi, Kariyawasam, Guez et al.: "Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass." in: Diabetologia, Vol. 57, Issue 5, pp. 960-9, 2014 (PubMed).

Hosts (73), (3), (3), (1)
Reactivities (70), (29), (27), (12), (12), (12), (12)
Applications (70), (46), (11), (10), (8), (5), (5), (5), (4)
Conjugates (4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (15), (7), (7), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN560675
394.24 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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