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Details for Product No. ABIN560675

Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A) (AA 674-763) antibody

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Antigen
Synonyms MNB, 2310043O08Rik, D16Ertd272e, D16Ertd493e, Dyrk, ENSMUSG00000074897, Gm10783, Mnbh, Mp86, mmb, PSK47, DYRK, DYRK1, HP86, MNBH, MRD7, mnb, DYRK1A, dyrk, dyrk1, hp86, mnbh
Epitope
»Alternatives AA 674-763
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 20 references available
Catalog no. ABIN560675
Quantity 100 µg
Price
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Immunogen DYRK1A (NP_001387, 674 a.a. ~ 763 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen sequence: NQGNQAYQNRPVAANTLDFG QNGAMDVNLTVYSNPRQETG IAGHPTYQFSANTGPAHYMT EGHLTMRQGADREESPMTGV CVQQSPVASS
Clone 7D10
Isotype IgG2b kappa
Characteristics Mouse monoclonal antibody raised against a partial recombinant DYRK1A.
Alternative Name DYRK1A
Background Gene: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms: DYRK, DYRK1, HP86, MNB, MNBH
Gene ID 1859
NCBI Accession NM_001396, NP_001387
Research Area Neurology, Neurogenesis
Application Notes Application specialization: Cell lysate, Recombinant protein
Restrictions For Research Use only
Buffer 1x PBS, pH 7.2
Storage -20 °C
Storage Comment Store at -20 °C or lower. Aliquot to avoid repeated freezing and thawing.
Product cited in: Aranda, Alvarez, Turró et al.: "Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 5899-911, 2008 (PubMed).

Hamelet, Noll, Ripoll et al.: "Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice." in: Biochemical and biophysical research communications, Vol. 378, Issue 3, pp. 673-7, 2008 (PubMed).

Guedj, Sébrié, Rivals et al.: "Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A." in: PLoS ONE, Vol. 4, Issue 2, pp. e4606, 2009 (PubMed).

Scales, Lin, Kraus et al.: "Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2424-35, 2009 (PubMed).

Lee, Ha, Kim et al.: "Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33343-51, 2009 (PubMed).

Noll, Planque, Ripoll et al.: "DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase." in: PLoS ONE, Vol. 4, Issue 10, pp. e7540, 2009 (PubMed).

Raaf, Noll, Cherifi et al.: "Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats." in: International journal of cardiology, Vol. 145, Issue 2, pp. 306-7, 2010 (PubMed).

Guo, Williams, Schug et al.: "DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13223-32, 2010 (PubMed).

Lilienthal, Kolanowski, Becker: "Development of a sensitive non-radioactive protein kinase assay and its application for detecting DYRK activity in Xenopus laevis oocytes." in: BMC biochemistry, Vol. 11, pp. 20, 2010 (PubMed).

Toiber, Azkona, Ben-Ari et al.: "Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations." in: Neurobiology of disease, Vol. 40, Issue 1, pp. 348-59, 2010 (PubMed).

Sheppard, Plattner, Rubin et al.: "Altered regulation of tau phosphorylation in a mouse model of down syndrome aging." in: Neurobiology of aging, Vol. 33, Issue 4, pp. 828.e31-44, 2012 (PubMed).

Ahmed, Sturgeon, Ellison et al.: "Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome." in: Journal of proteome research, Vol. 11, Issue 2, pp. 1251-63, 2012 (PubMed).

Park, Sung, Park et al.: "Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP." in: Journal of cell science, Vol. 125, Issue Pt 1, pp. 67-80, 2012 (PubMed).

Guedj, Pereira, Najas et al.: "DYRK1A: a master regulatory protein controlling brain growth." in: Neurobiology of disease, Vol. 46, Issue 1, pp. 190-203, 2012 (PubMed).

Malinge, Bliss-Moreau, Kirsammer et al.: "Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome." in: The Journal of clinical investigation, Vol. 122, Issue 3, pp. 948-62, 2012 (PubMed).

Planque, Dairou, Noll et al.: "Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain." in: Journal of molecular neuroscience : MN, 2012 (PubMed).

Abekhoukh, Planque, Ripoll et al.: "Dyrk1A, a serine/threonine kinase, is involved in ERK and Akt activation in the brain of hyperhomocysteinemic mice." in: Molecular neurobiology, Vol. 47, Issue 1, pp. 105-16, 2013 (PubMed).

Guo, Kesimer, Tolun et al.: "The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status." in: Scientific reports, Vol. 2, pp. 640, 2012 (PubMed).

Spellman, Ahmed, Dubach et al.: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, 2012 (PubMed).

Altafaj, Martín, Ortiz-Abalia et al.: "Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome." in: Neurobiology of disease, Vol. 52, pp. 117-27, 2013 (PubMed).

Alternatives for antigen "Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A)", type "Antibodies"
Hosts (52), (3), (2), (1)
Reactivities (50), (29), (27), (13), (13), (13), (12), (1), (1), (1), (1)
Applications (48), (24), (10), (8), (7), (4), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (10), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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