MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody

Details for Product No. ABIN567786
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Antigen
Synonyms MAD2, HSMAD2, AA673185, XMad2, mad2, cb408, zgc:112133, MAD2L1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(67), (20), (17), (16), (14), (12), (1), (1)
Host
Mouse
(44), (20), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(56), (27), (17), (15), (10), (7), (5), (3), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN567786
Quantity 0.1 mg
Price
489.50 $   Plus shipping costs $45.00
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Immunogen Recombinant Human MAD2.
Clone 2G9
Isotype IgG1
Specificity This antibody reacts with MAD2 (25 kDa) on Western blotting and Immunoprecipitation.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name MAD2L1
Background Some of the spindle checkpoint components are evolutionarily conserved from yeast to human. They include mitotic arrest deficiency 1 (MAD1), MAD2, MAD3/BUBR1, budding uninhibited by benomyl 1 (BUB1), BUB3, and monopolar spindle 1 (MPS1). MAD1 interacts with several checkpoint proteins, forming a complex with MAD2 and recruiting MAD2 to unattached kinetochores. MAD1 and Cdc20 can bind MAD2, but these two bindings are exclusive. They share a 10-residue MAD2-binding motif. It has been suggested that MAD1 acts as a positive regulator and a competitive inhibitor of the MAD2-Cdc20 complex.
Alternate names: MAD2, Mitotic spindle assembly checkpoint protein MAD2A
Gene ID 4085
NCBI Accession NP_002349
UniProt Q13257
Research Area Cell Cycle
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50% Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C.
Expiry Date 12 months
Supplier Images
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (2) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (Image 2)
Background publications Sudakin, Chan, Yen: "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2." in: The Journal of cell biology, Vol. 154, Issue 5, pp. 925-36, 2001 (PubMed).

Wei, Chou, Ou et al.: "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 7748-57, 2005 (PubMed).

Hosts (44), (20), (5)
Reactivities (67), (20), (17), (16), (14), (12), (1), (1)
Applications (56), (27), (17), (15), (10), (7), (5), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (4), (3), (2), (1), (1), (1), (1), (1)
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