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MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody

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Synonyms cb408, zgc:112133, MAD2L1, mad2, XMad2, AA673185, MAD2, HSMAD2
Human, Mouse (Murine), Rat (Rattus)
(107), (28), (25), (4), (4), (4), (2), (2), (1), (1)
(68), (24), (15), (1)
Clonality (Clone)
Monoclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunoprecipitation (IP), Western Blotting (WB)
(92), (40), (21), (19), (18), (17), (11), (4), (2), (1), (1), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Human MAD2.
Clone 2G9
Isotype IgG1
Specificity This antibody reacts with MAD2 (25 kDa) on Western blotting and Immunoprecipitation.
Purification Protein-A Agarose Chromatography of hybridoma supernatant.
Alternative Name MAD2L1 (MAD2L1 Antibody Abstract)
Background Some of the spindle checkpoint components are evolutionarily conserved from yeast to human. They include mitotic arrest deficiency 1 (MAD1), MAD2, MAD3/BUBR1, budding uninhibited by benomyl 1 (BUB1), BUB3, and monopolar spindle 1 (MPS1). MAD1 interacts with several checkpoint proteins, forming a complex with MAD2 and recruiting MAD2 to unattached kinetochores. MAD1 and Cdc20 can bind MAD2, but these two bindings are exclusive. They share a 10-residue MAD2-binding motif. It has been suggested that MAD1 acts as a positive regulator and a competitive inhibitor of the MAD2-Cdc20 complex.Synonyms: MAD2, Mitotic spindle assembly checkpoint protein MAD2A
Gene ID 4085
NCBI Accession NP_002349
UniProt Q13257
Research Area Cell Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.2 containing 50 % Glycerol without preservatives.
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
Western Blotting (WB) image for anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (ABIN567786) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody
Western Blotting (WB) image for anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (ABIN567786) anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibody (Image 2)
Background publications Wei, Chou, Ou et al.: "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 7748-57, 2005 (PubMed).

Sudakin, Chan, Yen: "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2." in: The Journal of cell biology, Vol. 154, Issue 5, pp. 925-36, 2001 (PubMed).

Catalog No. ABIN567786
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