FASL antibody (PE)

Catalog No. ABIN614579

Product Details anti-FASL Antibody (PE)

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reactivity: Mouse, Rat

Host: Hamster

Clonality: Monoclonal

Conjugate: This FASL antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Specificity: Recognizes both Mouse and Rat CD178. Clone MFL4 is reported to block CD178/CD95 induced apoptosis. We recommend the use of AM20860LE-N for functional studies.

Purification: Affinity Chromatography on Protein G

Immunogen: B6 Mouse FasL/BHK cells

Clone: MFL4

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 0.25 mL distilled water

Buffer: PBS containing 0.09 % Sodium Azide as preservative, 1 % BSA and 5 % Sucrose as stabilizers

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody Prior to and after reconstitution at 2-8 °C.

Target Details for FASL

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Alternative Name: CD178 / Fas Ligand (FASL Products)

Background: CD178, otherwise known as Fas Ligand/ CD95L, a 40 kDa type II transmembrane glycoprotein and member of the TNF/NGF superfamily, expressed by activated T cells and NK cells, which can be induced on a variety of cells by radiation, heat shock, chemotherapeutic agents and viral infection. CD178 acts as a key effector of cytotoxicity and in the regulation of immune responses. The binding of CD178 to its receptor CD95 (Fas), induces Fas-mediated apoptosis of target cells, and may be involved in the induction of peripheral tolerance and neutrophil chemotaxis. The binding of decoy receptor 3 (DcR3) to CD178 has been shown to inhibit CD178-mediated apoptosis.Synonyms: APT1LG1, APTL, Apoptosis antigen ligand, CD95L protein, FASL, FASLG, Fas antigen ligand, TNFSF6, Tumor necrosis factor ligand superfamily member 6

Gene ID: 14103

NCBI Accession: NP_034307

UniProt: P41047

Pathways: Apoptosis, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity